Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

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dc.contributor.authorArtigas, M.
dc.contributor.authorLoth, D.
dc.contributor.authorWain, L.
dc.contributor.authorGharib, S.
dc.contributor.authorObeidat, M.
dc.contributor.authorTang, W.
dc.contributor.authorZhai, G.
dc.contributor.authorZhao, J.
dc.contributor.authorSmith, A.
dc.contributor.authorHuffman, J.
dc.contributor.authorAlbrecht, E.
dc.contributor.authorJackson, C.
dc.contributor.authorEvans, D.
dc.contributor.authorCadby, G.
dc.contributor.authorFornage, M.
dc.contributor.authorManichaikul, A.
dc.contributor.authorLopez, L.
dc.contributor.authorJohnson, T.
dc.contributor.authorAldrich, M.
dc.contributor.authorAspelund, T.
dc.contributor.authoret al.
dc.date.issued2011
dc.description.abstractPulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10−8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
dc.description.statementofresponsibilityMaría Soler Artigas ... Lyle J Palmer ... et al.
dc.identifier.citationNature Genetics, 2011; 43(11):1082-1090
dc.identifier.doi10.1038/ng.941
dc.identifier.issn1061-4036
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/2440/86656
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/403981
dc.rights© 2011 Nature America Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1038/ng.941
dc.subjectInternational Lung Cancer Consortium
dc.subjectGIANT consortium
dc.subjectHumans
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectRespiratory Function Tests
dc.subjectChild
dc.subjectGenome-Wide Association Study
dc.subjectWhite People
dc.titleGenome-wide association and large-scale follow up identifies 16 new loci influencing lung function
dc.typeJournal article
pubs.publication-statusPublished

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