A study to investigate the impact of the initiation of highly active antiretroviral therapy on the hepatitis C virus viral load in HIV/HCV-coinfected patients

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dc.contributor.authorMijch, A.
dc.contributor.authorSasadeusz, J.
dc.contributor.authorHellard, M.
dc.contributor.authorDunne, M.
dc.contributor.authorMcCaw, R.
dc.contributor.authorBowden, S.
dc.contributor.authorGowans, E.
dc.date.issued2005
dc.description.abstractChanges in the hepatitis C virus (HCV) viral load (VL) were assessed in a retrospective study of 50 HIV/HCV-coinfected patients who initiated highly active antiretroviral therapy (HAART). Most patients responded to HAART [during the first 6 months, plasma HIV VL fell by a mean 1.39 log₁₀, becoming undetectable (<400 copies/ml) in 22% and CD4+ T cells increased by a mean of 100 cells/µl], but surprisingly, 27 (54%) showed some rise and 25 (50%) showed a significant increase in the HCV VL. This figure was considered to be a minimum estimate. A majority of the patients showed an increase of less than 1 log₁₀ that was associated with a rapid decrease in the HIV VL, whereas an increase in the HCV VL of greater than 1 log₁₀, noted in eight patients, was associated with a baseline CD4+ cell count of less than 200 cells/µl. The increase in the HCV VL was not associated with hepatitis as determined by raised alanine transferase.
dc.description.statementofresponsibilityAnne Mijch, Joseph Sasadeusz, Margaret Hellard, Mandy Dunne, Rhonda McCaw, Scott Bowden and Eric J Gowans
dc.identifier.citationAntiviral Therapy, 2005; 10(2):277-284
dc.identifier.doi10.1177/135965350501000211
dc.identifier.issn1359-6535
dc.identifier.issn2040-2058
dc.identifier.orcidGowans, E. [0000-0002-4274-8311]
dc.identifier.urihttp://hdl.handle.net/2440/66389
dc.language.isoen
dc.publisherInt Medical Press Ltd
dc.rights© 2005 International Medical Press
dc.source.urihttps://doi.org/10.1177/135965350501000211
dc.subjectHumans
dc.subjectHepacivirus
dc.subjectHepatitis C
dc.subjectHIV Infections
dc.subjectReverse Transcriptase Inhibitors
dc.subjectProtease Inhibitors
dc.subjectCD4 Lymphocyte Count
dc.subjectAntiretroviral Therapy, Highly Active
dc.subjectViral Load
dc.subjectRetrospective Studies
dc.subjectCohort Studies
dc.subjectTime Factors
dc.subjectAdult
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.titleA study to investigate the impact of the initiation of highly active antiretroviral therapy on the hepatitis C virus viral load in HIV/HCV-coinfected patients
dc.typeJournal article
pubs.publication-statusPublished

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