Biocultural Drivers of Salivary Microbiota in Australian Aboriginal and Torres Strait Islander Children

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dc.contributor.authorHandsley-Davis, M.
dc.contributor.authorSkelly, E.
dc.contributor.authorJohnson, N.W.
dc.contributor.authorKapellas, K.
dc.contributor.authorLalloo, R.
dc.contributor.authorKroon, J.
dc.contributor.authorWeyrich, L.S.
dc.date.issued2021
dc.descriptionPublished: 18 March 2021.
dc.description.abstractAustralian Aboriginal and Torres Strait Islander children experience unacceptably high rates of dental caries compared to their non-Indigenous Australian counterparts. Dental caries significantly impacts the quality of life of children and their families, particularly in remote communities. While many socioeconomic and lifestyle factors impact caries risk, the central role of the oral microbiota in mediating dental caries has not been extensively investigated in these communities. Here, we examine factors that shape diversity and composition of the salivary microbiota in Aboriginal and Torres Strait Islander children and adolescents living in the remote Northern Peninsula Area (NPA) of Far North Queensland. We employed 16S ribosomal RNA amplicon sequencing to profile bacteria present in saliva collected from 205 individuals aged 4–17 years from the NPA. Higher average microbial diversity was generally linked to increased age and salivary pH, less frequent toothbrushing, and proxies for lower socioeconomic status (SES). Differences inmicrobial composition were significantly related to age, salivary pH, SES proxies, and active dental caries. Notably, a feature classified as Streptococcus sobrinus increased in abundance in children who reported less frequent tooth brushing. A specific Veillonella feature was associated with caries presence, while features classified as Actinobacillus/Haemophilus and Leptotrichia were associated with absence of caries; a Lactobacillus gasseri feature increased in abundance in severe caries. Finally, we statistically assessed the interplay between dental caries and caries risk factors in shaping the oral microbiota. These data provide a detailed understanding of biological, behavioral, and socioeconomic factors that shape the oral microbiota and may underpin caries development in this group. This information can be used in the future to improve tailored caries prevention and management options
dc.description.statementofresponsibilityMatilda Handsley-Davis, Emily Skelly, Newell W. Johnson, Kostas Kapellas, Ratilal Lalloo, Jeroen Kroon, and Laura S. Weyrich
dc.identifier.citationFrontiers in Oral Health, 2021; 2:641328-1-641328-11
dc.identifier.doi10.3389/froh.2021.641328
dc.identifier.issn2673-4842
dc.identifier.issn2673-4842
dc.identifier.orcidHandsley-Davis, M. [0000-0001-9088-5268]
dc.identifier.orcidKapellas, K. [0000-0002-3761-9953]
dc.identifier.orcidLalloo, R. [0000-0001-5822-1269]
dc.identifier.urihttps://hdl.handle.net/2440/134922
dc.language.isoen
dc.publisherFrontiers
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1081320
dc.relation.granthttp://purl.org/au-research/grants/arc/FT180100407
dc.relation.granthttp://purl.org/au-research/grants/arc/CE170100015
dc.rights© 2021 Handsley-Davis, Skelly, Johnson, Kapellas, Lalloo, Kroon and Weyrich. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.source.urihttps://doi.org/10.3389/froh.2021.641328
dc.subjectBacteria; Community dentistry; Dental caries; Ecology; Microbiology
dc.titleBiocultural Drivers of Salivary Microbiota in Australian Aboriginal and Torres Strait Islander Children
dc.typeJournal article
pubs.publication-statusPublished

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