A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes

Simple item page
dc.contributor.authorBlodgett, J.M.
dc.contributor.authorTheou, O.
dc.contributor.authorHowlett, S.E.
dc.contributor.authorWu, F.C.W.
dc.contributor.authorRockwood, K.
dc.date.issued2016
dc.description.abstractabnormal laboratory test results accumulate with age and can be common in people with few clinically detectable health deficits. A frailty index (FI) based entirely on common physiological and laboratory tests (FI-Lab) might offer pragmatic and scientific advantages compared with a clinical FI (FI-Clin).to compare the FI-Lab with the FI-Clin and to assess their individual and combined relationships with mortality and other adverse health outcomes.secondary analysis of the eight-centre, longitudinal European Male Ageing Study (EMAS) of community-dwelling men aged 40-79 at baseline. Follow-up assessment occurred 4.4 ± 0.3 (mean ± SD) years later.we constructed a 23-item FI using common laboratory tests, blood pressure and pulse (FI-Lab), compared it with a previously validated 39-item FI using self-report and performance-based measures (FI-Clin) and finally combined both FIs to create a 62-item FI-Combined. Outcomes were all-cause mortality, institutionalisation, doctor visits, medication use, self-reported health, falls and fractures.the mean FI-Lab score was 0.28 ± 0.11, the FI-Clin was 0.13 ± 0.11 and FI-Combined was 0.19 ± 0.09. Age-adjusted models demonstrated that each FI was associated with mortality [HR (CI) FI-Lab: 1.04 (1.03-1.06); FI-Clin: 1.05 (1.04-1.06); FI-Combined: 1.07 (1.06-1.09)], institutionalisation, doctor visits, medication use, self-reported health and falls. Combined in a model with FI-Clin, the FI-Lab remained independently associated with mortality, institutionalisation, doctor visits, medication use and self-reported health.the FI-Lab detected an increased risk of adverse health outcomes alone and in combination with a clinical FI; further evaluation of the feasibility of the FI-Lab as a frailty screening tool within hospital care settings is needed.
dc.description.statementofresponsibilityJoanna M. Blodgett, Olga Theou, Susan E. Howlett, Frederick C. W. Wu, Kenneth Rockwood
dc.identifier.citationAge and Ageing, 2016; 45(4):463-468
dc.identifier.doi10.1093/ageing/afw054
dc.identifier.issn0002-0729
dc.identifier.issn1468-2834
dc.identifier.orcidTheou, O. [0000-0001-6460-782X]
dc.identifier.urihttp://hdl.handle.net/2440/123141
dc.language.isoen
dc.publisherOxford University Press
dc.rights© The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.
dc.source.urihttps://doi.org/10.1093/ageing/afw054
dc.subjectFrailty; frail older people; pre-clinical frailty; ageing; mortality
dc.titleA frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications