SNP associations and genetic-parameter estimation for nose and hoof pigmentation in Corriedale sheep

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dc.contributor.authorAldersey, J.E.
dc.contributor.authorKhatkar, M.S.
dc.contributor.authorBlackwood, P.J.
dc.contributor.authorBlackwood, C.E.
dc.contributor.authorPitchford, J.M.
dc.contributor.authorGordon, H.
dc.contributor.authorWelsh, S.C.
dc.contributor.authorPitchford, W.S.
dc.contributor.editorHatcher, S.
dc.date.issued2023
dc.descriptionPublished Online 7/6/23
dc.description.abstractContext. Quantity and quality of both meat and wool are important for selection programs of the dual-purpose Corriedale sheep. In Corriedales, black pigmentation of nose skin and hooves is preferred as part of the breed standard. However, within the breed, pigmentation can vary from none to complete pigmentation. Aims. The aim was to discover single-nucleotide polymorphisms (SNPs) and genes associated with nose and hoof pigmentation and to estimate genetic parameters of nose and hoof pigmentation, wool traits and meat traits. Methods. The phenotype and genotype data on Corriedale lambs (n = 764) produced from 44 sires (12 studs) and 300 ewes in 2017–2019 were used in this study. Lambs were slaughtered at 6–7 months of age. Nose pigmentation and hoof pigmentation were scored on a five-point scale, where no pigmentation was scored 0 and complete pigmentation was scored 5. Wool-and meat-quality traits were measured, including greasy fleece weight, fibre diameter, weaning weight, hot standard carcass weight and intramuscular fat percentage. The lambs were genotyped with the GGPOvine50K SNP chip. A genome-wide association study (GWAS) was conducted. Genetic parameters and bivariate analyses were estimated using ASReml-R. Results. The lambs had a mean nose-pigmentation score of 3.69 and hoof-pigmentation score of 4.12. The nose pigmentation (h2 = 0.58) and hoof pigmentation (h2 = 0.51) were highly heritable and highly correlated (rG = 0.73). The GWAS identified a genome-wide significant SNP (OAR19_33278780.1) associated with nose pigmentation (q-value = 0.04). This SNP is positioned in a known pigmentation gene, melanocyte-inducing transcription factor (MITF ). The same SNP was the sixth-most associated SNP for hoof pigmentation but did not reach significance level. OAR19_33278780.1 also had a significant effect on back conformation and weaning weight. Conclusions. The results of these analyses have provided information and an understanding of the genetics for pigmentation of nose and hooves in Corriedale sheep. Implications. Nose and hoof pigmentation are highly genetically correlated with each other, but with no negative effects on production traits.
dc.description.statementofresponsibilityJ. E. Aldersey, M. S. Khatkar, P. J. Blackwood, C. E. Blackwood, J. M. Pitchford, H. Gordon, S. C. Welsh and W. S. Pitchford
dc.identifier.citationAnimal Production Science, 2023; 63(10-11):1136-1147
dc.identifier.doi10.1071/an22462
dc.identifier.issn1836-0939
dc.identifier.issn1836-5787
dc.identifier.orcidKhatkar, M.S. [0000-0002-4554-1404]
dc.identifier.orcidPitchford, W.S. [0000-0002-5213-3978]
dc.identifier.urihttps://hdl.handle.net/2440/138738
dc.language.isoen
dc.publisherCSIRO Publishing
dc.rights© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing. This is an open access article distributed under the Creative Commons Attribution 4.0 International License (CC BY). OPEN ACCESS
dc.source.urihttps://doi.org/10.1071/an22462
dc.subjectCorriedale; hoof; meat quality; MITF; nose skin; Ovis aries; pigment; wool quality
dc.titleSNP associations and genetic-parameter estimation for nose and hoof pigmentation in Corriedale sheep
dc.typeJournal article
pubs.publication-statusPublished

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