Animal cell division: a fellowship of the double ring?

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dc.contributor.authorSaint, R.
dc.contributor.authorSomers, W.
dc.contributor.organisationCentre for the Molecular Genetics of Development
dc.date.issued2003
dc.description.abstractDespite a century of research into the nature of animal cell division, a molecular explanation for the positioning of the actomyosin contractile ring has remained elusive. The discovery of a novel interaction between regulators of Rho family small GTPases has revealed a link between the mitotic microtubules and the contractile ring during the later stages of mitosis. The properties of the interacting Rho regulators suggest a molecular model for the positioning and initiation of contractile ring furrowing in animal cells. In this ‘double ring’ model, centralspindlin complexes, localized by the action of their kinesin-like protein component, position and activate a cortical equatorial ring of Rho GTPase exchange factors. The resulting ring of activated Rho would then trigger a cascade of events leading to formation and constriction of the contractile ring.
dc.identifier.citationJournal of Cell Science, 2003; 116(21):4277-4281
dc.identifier.doi10.1242/jcs.00816
dc.identifier.issn0021-9533
dc.identifier.issn1477-9137
dc.identifier.urihttp://hdl.handle.net/2440/47801
dc.language.isoen
dc.publisherCompany of Biologists Ltd
dc.source.urihttps://doi.org/10.1242/jcs.00816
dc.subjectCytokinesis
dc.subjectRho GTPase
dc.subjectPBL/Ect2 RhoGEF
dc.subjectContractile ring
dc.subjectPAV-KLP/MKLP1
dc.subjectCentral spindle
dc.subjectMicrotubules
dc.titleAnimal cell division: a fellowship of the double ring?
dc.typeJournal article
pubs.publication-statusPublished

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