Epidemiologic associations with cerebral palsy

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dc.contributor.authorO'Callaghan, M.
dc.contributor.authorMacLennan, A.
dc.contributor.authorGibson, C.
dc.contributor.authorMcMichael, G.
dc.contributor.authorHaan, E.
dc.contributor.authorBroadbent, J.
dc.contributor.authorGoldwater, P.
dc.contributor.authorDekker, G.
dc.date.issued2011
dc.description.abstract<h4>Objective</h4>To estimate epidemiologic risk factors for cerebral palsy.<h4>Methods</h4>Data were collected by linkage to state-based perinatal repositories and cerebral palsy registers and using a maternal questionnaire. The cohort included 587 individuals with cerebral palsy and 1,154 non-cerebral palsy controls.<h4>Results</h4>The following factors were associated with cerebral palsy: recorded maternal infection during pregnancy (41.4% patients compared with 31.3% controls; odds ratio [OR] 1.55, 95% confidence interval 1.26-1.91), small for gestational age ([birth weight less than third customized centile] 43.9% patients compared with 6.3% controls; OR 11.75, 6.25-22.08), gestational age less than 32 weeks (29.3% patients compared with 0.7% controls; OR 59.20, 28.87-121.38), multiple birth (OR 6.62, 4.00-10.95), a relative with cerebral palsy (OR 1.61, 1.12-2.32), breech position (13.7% patients compared with 6.0% controls; OR 2.48, 1.76-3.49), bleeding at any time in pregnancy (29.3% patients compared with 16.9% controls; OR 2.04, 1.61-2.58), male sex (58.8% patients compared with 45.8% controls; OR 1.68, 1.38-2.06), multiple miscarriage (7.7% patients compared with 3.5% controls; OR 2.30, 1.38-3.82), smoking (14.0% patients compared with 10.6% controls; OR 1.37, 1.02-1.85), and illicit drug use (3.3% patients compared with 1.5% controls; OR 2.22, 1.14-4.30). Factors not associated with cerebral palsy were "disappearing twin," diabetes, maternal body mass index, hypertension, alcohol consumption, anemia, maternal hypothyroidism, forceps or vacuum delivery, and maternal age.<h4>Conclusion</h4>Preterm birth, intrauterine growth restriction, perinatal infection, and multiple birth present the largest risks for a cerebral palsy outcome. Reassuringly, upper respiratory tract and gastrointestinal infections during pregnancy were not associated with cerebral palsy.<h4>Level of evidence</h4>II.
dc.description.statementofresponsibilityMichael E. O'Callaghan, Alastair H. MacLennan, Catherine S. Gibson, Gai L. McMichael, Eric A. Haan, Jessica L. Broadbent, Paul N. Goldwater, and Gustaaf A. Dekker for the Australian Collaborative Cerebral Palsy Research Group
dc.identifier.citationObstetrics and Gynecology, 2011; 118(3):576-582
dc.identifier.doi10.1097/AOG.0b013e31822ad2dc
dc.identifier.issn0029-7844
dc.identifier.issn1873-233X
dc.identifier.orcidO'Callaghan, M. [0000-0001-5038-5859] [0000-0002-8178-9714]
dc.identifier.orcidMcMichael, G. [0000-0002-6811-5301]
dc.identifier.orcidHaan, E. [0000-0002-7310-5124]
dc.identifier.orcidGoldwater, P. [0000-0003-4822-8488]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.urihttp://hdl.handle.net/2440/66801
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rights© 2011 The American College of Obstetricians and Gynecologists
dc.source.urihttps://doi.org/10.1097/aog.0b013e31822ad2dc
dc.subjectAustralian Collaborative Cerebral Palsy Research Group
dc.subjectHumans
dc.subjectPregnancy Complications, Infectious
dc.subjectCerebral Palsy
dc.subjectFetal Death
dc.subjectFetal Growth Retardation
dc.subjectBreech Presentation
dc.subjectPremature Birth
dc.subjectApgar Score
dc.subjectPregnancy Outcome
dc.subjectRisk Factors
dc.subjectSmoking
dc.subjectSex Factors
dc.subjectPregnancy
dc.subjectPregnancy, Multiple
dc.subjectTwins
dc.subjectAdult
dc.subjectInfant, Newborn
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.titleEpidemiologic associations with cerebral palsy
dc.typeJournal article
pubs.publication-statusPublished

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