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Disperse-and-collect approach for the type-selective detection of matrix metalloproteinases in porous silicon resonant microcavities

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dc.contributor.authorKrismastuti, F.S.H.
dc.contributor.authorDewi, M.R.
dc.contributor.authorPrieto Simon, B.
dc.contributor.authorNann, T.
dc.date.issued2017
dc.descriptionData source: Supporting information, http://pubs.acs.org/doi/suppl/10.1021/acssensors.6b00442
dc.description.abstractWe report on the design and testing of photonic biosensors for the type-selective detection of different types of matrix metalloproteinases (MMPs). The ability to detect a panel of different MMP types has important implications for prognosis of wound healing. We combine the immunocapture of MMPs on dispersed magnetic nanoparticles modified with antibodies specific for target MMPs (immuno-magNPs) with subsequent MMP detection upon fluorogenic peptide cleavage in porous silicon resonant microcavity (pSiRM) architectures. We report fast, sensitive, and type-selective detection of MMPs directly in wound fluid. This study sets the scene for downstream developments of multiparametric biosensors as point-of-care (POC) prognostic tools that may step-change chronic wound management.
dc.identifier.citationACS Sensors, 2017; 2(2):203-209
dc.identifier.doi10.1021/acssensors.6b00442
dc.identifier.issn2379-3694
dc.identifier.issn2379-3694
dc.identifier.urihttps://hdl.handle.net/11541.2/128342
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rightsCopyright 2017 American Chemical Society
dc.source.urihttps://doi.org/10.1021/acssensors.6b00442
dc.subjectchronic wound management
dc.subjectmagnetic nanoparticles
dc.subjectmatrix metalloproteinases
dc.subjectmultiparametric detection
dc.subjectporous silicon resonant microcavity
dc.titleDisperse-and-collect approach for the type-selective detection of matrix metalloproteinases in porous silicon resonant microcavities
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916149108101831

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