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Therapeutic potential of tea tree oil for scabies

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dc.contributor.authorThomas, J.
dc.contributor.authorCarson, C.F.
dc.contributor.authorPeterson, G.M.
dc.contributor.authorWalton, S.F.
dc.contributor.authorHammer, K.A.
dc.contributor.authorNaunton, M.
dc.contributor.authorDavey, R.C.
dc.contributor.authorSpelman, T.
dc.contributor.authorDettwiller, P.
dc.contributor.authorKyle, G.
dc.contributor.authorCooper, G.M.
dc.contributor.authorBaby, K.E.
dc.date.issued2016
dc.description.abstractGlobally, scabies affects more than 130 million people at any time. In the developed world, outbreaks in health institutions and vulnerable communities result in a significant economic burden. A review of the literature demonstrates the emergence of resistance toward classical scabicidal treatments and the lack of effectiveness of currently available scabicides in reducing the inflammatory skin reactions and pyodermal progression that occurs in predisposed patient cohorts. Tea tree oil (TTO) has demonstrated promising acaricidal effects against scabies mites in vitro and has also been successfully used as an adjuvant topical medication for the treatment of crusted scabies, including cases that did not respond to standard treatments. Emerging acaricide resistance threatens the future usefulness of currently used gold standard treatments (oral ivermectin and topical permethrin) for scabies. The imminent development of new chemical entities is doubtful. The cumulative acaricidal, antibacterial, antipruritic, anti-inflammatory, and wound healing effects of TTO may have the potential to successfully reduce the burden of scabies infection and the associated bacterial complications. This review summarizes current knowledge on the use of TTO for the treatment of scabies. On the strength of existing data for TTO, larger scale, randomized controlled clinical trials are warranted.
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene, 2016; 94(2):258-266
dc.identifier.doi10.4269/ajtmh.14-0515
dc.identifier.issn0002-9637
dc.identifier.issn1476-1645
dc.identifier.urihttps://hdl.handle.net/11541.2/32371
dc.language.isoen
dc.publisherAMER SOC TROP MED & HYGIENE
dc.rightsCopyright 2016 The American Society of Tropical Medicine and Hygiene. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.4269/ajtmh.14-0515
dc.subjectHumans
dc.subjectScabies
dc.subjectTea Tree Oil
dc.subjectAcaricides
dc.titleTherapeutic potential of tea tree oil for scabies
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12257479630001831 13257479620001831 1476-1645-article-p258
ror.mmsid9916713827101831

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