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Implications of Altered Endosomal-Lysosomal Biogenesis in Melanoma Pathogenesis

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dc.contributor.authorLam, G.
dc.contributor.authorMartini, C.
dc.contributor.authorSorvina, A.
dc.contributor.authorHickey, S.
dc.contributor.authorHindes, M.
dc.contributor.authorWaugh, D.
dc.contributor.authorO'Leary, J.J.
dc.contributor.authorBrooks, D.
dc.contributor.authorLogan, J.
dc.date.issued2025
dc.description.abstractMelanoma exhibits inherent heterogeneity and a high metastatic propensity, posing significant challenges for diagnosis, prognosis, and treatment. There are recognized problems with the visual detection of melanoma, such as amelanocytic lesions, which indicate that melanogenesis is downstream of the critical pathogenesis. The endosome–lysosome system regulates trafficking to control melanogenesis, and endosome function/signaling is directly impacted by common melanoma mutations. The endosomal–lysosomal system is also integrally involved in the regulation of fundamental cellular processes that are associated with other key hallmarks of this cancer. This traditional narrative review explores the relationship between altered endosomal–lysosomal biogenesis, aberrant melanogenesis, and oncogenic function in melanoma, including the potential effects on proliferation, invasion, and metastasis. Elucidating the molecular mechanisms underpinning the altered endosomal–lysosomal biology in melanoma is important as this has the potential to define new diagnostic and prognostic biomarkers to improve patient management.
dc.identifier.citationInternational Journal of Molecular Sciences, 2025; 26(20, article no. 10113):1-15
dc.identifier.doi10.3390/ijms262010113
dc.identifier.issn1422-0067
dc.identifier.issn1422-0067
dc.identifier.orcidHickey, S. [0000-0002-3063-531X]
dc.identifier.orcidHindes, M. [0009-0002-8117-5672]
dc.identifier.orcidBrooks, D. [0000-0001-9098-3626]
dc.identifier.urihttps://hdl.handle.net/11541.2/44766
dc.language.isoen
dc.publisherMDPIAG
dc.relation.fundingRattigan Family Trust
dc.relation.fundingUniversity of South Australia
dc.relation.fundingProstate Cancer Foundation of Australia PIRA 1023
dc.rightsCopyright 2025 The author(s) (https://creativecommons.org/licenses/by/4.0/) Access Condition Notes: This is an open access article
dc.source.urihttps://doi.org/10.3390/ijms262010113
dc.subjectEndosomal–lysosomal biogenesis
dc.subjectmelanoma
dc.subjectmelanoma pathogenesis
dc.subjectbiomarkers
dc.subjectEndosomes
dc.subjectLysosomes
dc.subjectAnimals
dc.subjectHumans
dc.subjectMelanins
dc.subjectSignal Transduction
dc.subjectOrganelle Biogenesis
dc.titleImplications of Altered Endosomal-Lysosomal Biogenesis in Melanoma Pathogenesis
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12308266430001831 13308266420001831 Open Access Published Version
ror.mmsid9917080048601831

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