Altered insulin-like growth factor binding proteins
Date
2009
Authors
Forbes, B.
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Patent
Citation
Statement of Responsibility
Invented by B. Forbes; assigened to University of Adelaide; A.P.T. Patent and Trade Mark Attorneys agent for inventors.
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Abstract
Altered IGFBPs are able to bind IGF but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by the use of these altered IGFBPs.
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Description
PATENT: B. Forbes (Assignee: University of Adelaide). AU 2003/243829 B2 (PCT/AU2003/000898) filed Jul 11, 2003; published Jan 22, 2004; accepted journal date Oct 23, 2008