Current studentsExisting staffContact us
 

Demographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Aging Study (FAMAS)

Simple item page
dc.contributor.authorAtlantis, E.
dc.contributor.authorMartin, S.
dc.contributor.authorHaren, M.
dc.contributor.authorO'Loughlin, P.
dc.contributor.authorTaylor, A.
dc.contributor.authorAnand Ivell, R.
dc.contributor.authorIvell, R.
dc.contributor.authorWittert, G.
dc.date.issued2009
dc.description.abstractOBJECTIVE: Plasma androgen levels are inversely associated with health in men, the age-related decline of which may result from factors other than ageing per se. This study aimed to determine the effects of demographic, physical and lifestyle factors on age-related androgen status in men. DESIGN: An observational survey of a regionally representative male population residing in the North West regions of Adelaide, Australia. PARTICIPANTS: Study sample includes 1195 men aged 35-81 years with a response rate of 45.1%. MEASUREMENTS: Plasma levels of total testosterone (TT), bioavailable testosterone (BT), SHBG, insulin-like peptide 3 (INSL3), and gonadotrophins were measured along with an extensive list of demographic, physical and lifestyle factors including body composition, muscle strength and biomarkers of chronic diseases, physical activity, nutrition and smoking behaviour. RESULTS: Low TT was mostly associated with high abdominal fat and triglycerides and low muscle strength rather than ageing per se. Low BT was associated with increased age followed by high whole body fat percentage. BT and TT levels were higher in unmarried men and smokers. SHBG levels increased with age, but were also inversely associated with insulin and triglycerides. The Leydig cell specific factor INSL3 was the strongest biomarker associated with both TT and BT. CONCLUSIONS: Factors associated with low androgen status variably include high body fat percentage, low muscle strength and biomarkers of the metabolic syndrome. Reducing exposure to factors that adversely affect androgen status may improve the general health of ageing men by mechanisms yet to be defined.
dc.description.statementofresponsibilityEvan Atlantis, Sean A. Martin, Matthew T. Haren, Peter D. O'Loughlin, Anne W. Taylor, Ravinder Anand-Ivell, Richard Ivell, Gary A. Wittert and Members of the Florey Adelaide Male Ageing Study
dc.identifier.citationClinical Endocrinology, 2009; 71(2):261-272
dc.identifier.doi10.1111/j.1365-2265.2008.03463.x
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.orcidAtlantis, E. [0000-0001-5877-6141]
dc.identifier.orcidTaylor, A. [0000-0002-4422-7974]
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]
dc.identifier.urihttp://hdl.handle.net/2440/53763
dc.language.isoen
dc.publisherBlackwell Science Ltd
dc.relation.grantNHMRC
dc.rightsCopyright 2009 The Authors. Journal compilation Copyright 2009 Blackwell Publishing.
dc.source.urihttps://doi.org/10.1111/j.1365-2265.2008.03463.x
dc.subjectMembers of the Florey Adelaide Male Ageing Study
dc.subjectHumans
dc.subjectTestosterone
dc.subjectAndrogens
dc.subjectLife Style
dc.subjectHealth Status
dc.subjectBody Composition
dc.subjectAging
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectAustralia
dc.subjectMale
dc.subjectMuscle Strength
dc.titleDemographic, physical and lifestyle factors associated with androgen status: the Florey Adelaide Male Aging Study (FAMAS)
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications