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Meningeal mast cells as key effectors of stroke pathology

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dc.contributor.authorArac, A.
dc.contributor.authorGrimbaldeston, M.A.
dc.contributor.authorGalli, S.J.
dc.contributor.authorBliss, T.M.
dc.contributor.authorSteinberg, G.K.
dc.date.issued2019
dc.description.abstractStroke is the leading cause of adult disability in the United States. Because post-stroke inflammation is a critical determinant of damage and recovery after stroke, understanding the interplay between the immune system and the brain after stroke holds much promise for therapeutic intervention. An understudied, but important aspect of this interplay is the role of meninges that surround the brain. All blood vessels travel through the meningeal space before entering the brain parenchyma, making the meninges ideally located to act as an immune gatekeeper for the underlying parenchyma. Emerging evidence suggests that the actions of immune cells resident in the meninges are essential for executing this gatekeeper function. Mast cells (MCs), best known as pro-inflammatory effector cells, are one of the long-term resident immune cells in the meninges. Here, we discuss recent findings in the literature regarding the role of MCs located in the meningeal space and stroke pathology. We review the latest advances in mouse models to investigate the roles of MCs and MC-derived products in vivo, and the importance of using these mouse models. We examine the concept of the meninges playing a critical role in brain and immune interactions, re-evaluate the perspectives on the key effectors of stroke pathology, and discuss the opportunities and challenges for therapeutic development.
dc.description.statementofresponsibilityAhmet Arac, Michele A. Grimbaldeston, Stephen J. Galli, Tonya M. Bliss and Gary K. Steinberg
dc.identifier.citationFrontiers in Cellular Neuroscience, 2019; 13:126-1-126-10
dc.identifier.doi10.3389/fncel.2019.00126
dc.identifier.issn1662-5102
dc.identifier.issn1662-5102
dc.identifier.urihttp://hdl.handle.net/2440/120920
dc.language.isoen
dc.publisherFronters Media SA
dc.relation.grantNHMRC
dc.rightsCopyright © 2019 Arac, Grimbaldeston, Galli, Bliss and Steinberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.source.urihttps://doi.org/10.3389/fncel.2019.00126
dc.subjectMeninges; mast cells; ischemic stroke; meningeal mast cells; stroke pathology
dc.titleMeningeal mast cells as key effectors of stroke pathology
dc.typeJournal article
pubs.publication-statusPublished

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