Cardiometabolic risks in PCOS: a review of the current state of knowledge
Date
2019
Authors
Kakoly, N.S.
Moran, L.J.
Teede, H.J.
Joham, A.E.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Expert Review of Endocrinology and Metabolism, 2019; 14(1):23-33
Statement of Responsibility
NS Kakoly, LJ Moran, HJ Teede, AE Joham
Conference Name
Abstract
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% women of reproductive age. It is associated with a range of metabolic, reproductive, and psychological features. Current evidence indicates a role of PCOS in the development of metabolic and increased cardiovascular risk factors (CVRF) with implications for compromised cardiovascular endpoint disease, which may have a considerable impact on health and health care costs. Areas covered: Existing studies examining long-term cardiometabolic health in PCOS are heterogeneous with inconsistent findings. In the current review, we aim to explore and critically review retrospective, prospective, meta-analysis and review articles relating to PCOS on cardiometabolic risk factors and clinical consequences to summarize the evidence, note evidence gaps, and suggest implications for future research. Expert commentary: Although there is an established association between PCOS and metabolic health, implications on cardiac health are more uncertain with associations observed for CVRF and subclinical disease, yet limited and conflicting data on actual cardiovascular endpoints. There is a lack of population-based long-term studies examining cardiometabolic morbidity and mortality in PCOS with a need for further research to progress toward a better understanding of the long-term cardiometabolic impacts in women with PCOS.
School/Discipline
Dissertation Note
Provenance
Description
Published online: 15 Dec 2018
Access Status
Rights
© 2019 Informa UK Limited, trading as Taylor & Francis Group