Investigating the roles of 14-3-3ζ in the mammary tumour microenvironment /
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(Published version)
Date
2021
Authors
Poltavets, Valentina
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thesis
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Abstract
Breast cancer is the most diagnosed cancer among women. Late stage breast cancer can spread to other organs in the body and result in incurable disease. This research project investigated a protein called 14-3-3zeta in breast cancer using mouse as a model system. The main findings of this project are that 14-3-3zeta is important for maintaining normal breast tissue. When 14-3-3zeta is not present in cancer cells or is blocked using a drug, the cancers grow slowly. When 14-3-3zeta is present only in the cancer cells and not in the rest of the body the cancers also grow slowly. The levels of 14-3-3zeta in breast cancer may affect immune cells (cytotoxic T-cells) that have the ability to kill cancer cells. This study could be of benefit to the ongoing efforts to harnessing the body’s immune system to target advanced breast cancers.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Medical Science)--University of South Australia, 2021.
Provenance
Copyright 2021 Valentina Poltavets
Description
1 ethesis (xix, 164 pages) :
colour illustrations.
Includes bibliographical references (pages 130-164)
colour illustrations.
Includes bibliographical references (pages 130-164)
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506 0#$fstar $2Unrestricted online access