Effect of physiological changes in blood glucose on proximal gastric motor and sensory function
Date
1998
Authors
Verhaaen, M.A.M.T.
Rayner, C.K.
Andrews, J.M.
Doran, S.M.
Hebbard, G.S.
Samsom, M.
Horowitz, M.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Conference item
Citation
European Journal of Gastroenterology and Hepatology, 1998, vol.10, iss.12, pp.A86-A87
Statement of Responsibility
M.A.M.T. Verhagen, C.K Rayner, J.M. Andrews, S .M. Doran, G.S. Hebbard, M. Samsom and M. Horowitz
Conference Name
Netherlands Society of Gastroenterology and the Netherlands Society of Hepatology Spring Meeting
Abstract
Marked hyperglycaemia (blood glucose -14 mmol/1) slows gastric emptying in healthy subjects and diabetic patients, and increases proximal gastric compliance and the perception of gastric distension in normal subjects. Recent studies have shown that elevations of blood glucose within the physiological range (-9 mmol/1) also slow gastric emptying. This study aimed to determine whether of physiological changes in blood glucose affect proximal gastric compliance and the perception of gastric distension. Paired studies were conducted, in randomised order on a single day, on 10 fasting healthy volunteers at a blood glucose of 4 mmol/1 or 9 mmol/ I. A polyethylene bag was positioned in the proximal stomach, unfolded, and inflated with air by an electronic barostat. Both isovolumetric and isobaric distensions were performed (volume steps of JOO ml, or pressure steps of 1 mmHg). Each step was maintained for 3 min, and the maximum volume was limited to 800 ml. The pressure-volume relationsh ip of the proximal stomach was measured as an estimate of proximal gastric compliance. Sensations of fullness, nausea, bloating, abdominal discomfort, and hunger were scored using visual analogue scales in the last minute of each step. At blood glucose levels of both 4 mmol/1 and 9 mmol/1, sensations of fullness, nausea, abdominal discomfort, and bloating were related to volume in the bag (P s; 0.002) and pressure in the bag (P s; 0.006). Bag inflation did not influence the sensation of hunger. The blood glucose concentration had no effect on either the pressurevolume relationship (isovolumetric or isobaric), or the perception of an~ of the sensations. Co11c/11sio11s In the fasted state: i) elevations of blood glucose within the physiological range do not affect proximal gastric compliance, or the perception of proximal gastric distension; ii) The perception of hunger is not altered by proximal gastric distension.
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Dissertation Note
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© 1998 Lippincott Williams