Current studentsExisting staffContact us
 

Corticotropin-Releasing Hormone Causes Vasodilation in Human Skin via Mast Cell-Dependent Pathways

Simple item page
dc.contributor.authorCrompton, R.
dc.contributor.authorClifton, V.
dc.contributor.authorBisits, A.
dc.contributor.authorRead, M.
dc.contributor.authorSmith, R.
dc.contributor.authorWright, I.
dc.date.issued2003
dc.descriptionCopyright © 2003 by The Endocrine Society
dc.description.abstractCRH plays a central role as a mediator of the hypothalamic-pituitary-adrenal axis and stress response and is a potent vasodilator. Previously, we have shown that CRH causes a gender-specific vasodilation in human skin, although the mechanism by which CRH operates is unclear. CRH causes mast cell degranulation in rat skin. As such, histamine and other mast cell-derived factors may be indirectly responsible for the vasodilatory effects of CRH, although CRH is also known to act directly on the vasculature. CRH-induced vasodilation in human skin was examined using laser Doppler flowmetry and iontophoresis in adult females. CRH (1 nM) was administered iontophoretically to the forearm, and blood flow was measured simultaneously in the same area by laser Doppler. CRH-induced dilation of the skin microvasculature was significantly reduced in the presence of the mast cell degranulation inhibitor, sodium cromoglycate, the histamine H1-antagonist, promethazine, or the H2-antagonist, ranitidine. CRH-induced dilation was also significantly reduced in the presence of the nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor, piroxicam. These findings provide novel evidence that CRH-induced vasodilation in human skin occurs via mast cell degranulation and is principally mediated by histamine and, to a lesser extent, by prostacyclin and nitric oxide.
dc.description.statementofresponsibilityRenee Crompton, Vicki L. Clifton, Andrew T. Bisits, Mark A. Read, Roger Smith and Ian M. R. Wright
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2003; 88(11):5427-5432
dc.identifier.doi10.1210/jc.2003-030377
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.orcidClifton, V. [0000-0002-4892-6748]
dc.identifier.urihttp://hdl.handle.net/2440/46749
dc.language.isoen
dc.publisherEndocrine Society
dc.source.urihttps://doi.org/10.1210/jc.2003-030377
dc.subjectMast Cells
dc.subjectSkin
dc.subjectHumans
dc.subjectNitroprusside
dc.subjectPromethazine
dc.subjectCorticotropin-Releasing Hormone
dc.subjectNG-Nitroarginine Methyl Ester
dc.subjectReceptors, Corticotropin-Releasing Hormone
dc.subjectHistamine H1 Antagonists
dc.subjectVasodilator Agents
dc.subjectEnzyme Inhibitors
dc.subjectCell Degranulation
dc.subjectVasodilation
dc.subjectMiddle Aged
dc.subjectFemale
dc.titleCorticotropin-Releasing Hormone Causes Vasodilation in Human Skin via Mast Cell-Dependent Pathways
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Paediatrics publications