Methodological factors influencing inhalation bioaccessibility of metal(loid)s in PM₂.₅ using simulated lung fluid
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Date
2018
Authors
Kastury, F.
Smith, E.
Karna, R.R.
Scheckel, K.G.
Juhasz, A.L.
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Journal article
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Environmental Pollution, 2018; 241:930-937
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Abstract
In this study, methodological factors influencing the dissolution of metal(loid)s in simulated lung fluid(SLF) was assessed in order to develop a standardised method for the assessment of inhalation bioaccessibility in PM₂.₅. To achieve this aim, the effects of solid to liquid (S/L) ratio (1:100 to 1:5000),agitation (magnetic agitation, occasional shaking, orbital and end-over-end rotation), composition of SLF (artificial lysosomal fluid: ALF; phagolysosomal simulant fluid: PSF) and extraction time (1e120 h) onmetal(loid) bioaccessibility were investigated using PM₂.₅ from three Australian mining/smelting impacted soils and a certified reference material. The results highlighted that SLF composition significantly(p < 0.001) influenced metal(loid) bioaccessibility and that when a S/L ratio of 1:5000 and end-over-end rotation was used, metal(loid) solubility plateaued after approximately 24 h. Additionally, in order to assess the exposure of metal(loid)s via incidental ingestion of surface dust, PM₂.₅ was subjected to simulated gastro-intestinal tract (GIT) solutions and the results were compared to extraction using SLF. Although As bioaccessibility in SLF (24 h) was significantly lower than in simulated GIT solutions(p < 0.05), Pb bioaccessibility was equal to or significantly higher than that extracted using simulated GIT solutions (p < 0.05).
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Data source: Supplementary data, https://doi.org/10.1016/j.envpol.2018.05.094
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Copyright 2018 Elsevier
Access Condition Notes: Accepted manuscript available after 1 July 2020