Milestones in myoclonus

dc.contributor.author	Shibasaki, H.
dc.contributor.author	Thompson, P.
dc.date.issued	2011
dc.description.abstract	This review examines some of the advances in understanding myoclonus over the last 25 years. The classification of myoclonus into cortical, brainstem, and spinal forms has been consolidated, each with distinctive clinical characteristics and physiological mechanisms. New genetic causes of myoclonus have been identified, and the molecular basis of several of these conditions has been discovered. It is increasingly apparent that disease of the cerebellum is particularly important in the genesis of cortical reflex myoclonus. However, the precise mechanism and origin of myoclonus in many situations remain uncertain. Effective treatment of myoclonus remains limited, and the challenge lies ahead to develop more therapeutic options.
dc.description.statementofresponsibility	Hiroshi Shibasaki and Philip D. Thompson
dc.identifier.citation	Movement Disorders, 2011; 26(6):1142-1148
dc.identifier.doi	10.1002/mds.23673
dc.identifier.issn	0885-3185
dc.identifier.issn	1531-8257
dc.identifier.uri	http://hdl.handle.net/2440/69179
dc.language.iso	en
dc.publisher	Wiley-Liss
dc.rights	Copyright © 2011 Movement Disorder Society
dc.source.uri	https://doi.org/10.1002/mds.23673
dc.subject	myoclonus
dc.subject	clinical features
dc.subject	physiology
dc.subject	molecular genetics
dc.title	Milestones in myoclonus
dc.type	Journal article
pubs.publication-status	Published

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