Functional and well-defined β-sheet-assembled porous spherical shells by surface-guided peptide formation
Date
2015
Authors
Wibowo, S.H.
Sulistio, A.
Wong, E.H.H.
Blencowe, A.
Qiao, G.G.
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Advisors
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Type:
Journal article
Citation
Advanced Functional Materials, 2015; 25(21):3147-3156
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Abstract
<jats:p>Polypeptides have attracted widespread attention as building blocks for complex materials due to their ability to form higher‐ordered structures such as <jats:italic>β</jats:italic>‐sheets. However, the ability to precisely control the formation of well‐defined <jats:italic>β</jats:italic>‐sheet‐assembled materials remains challenging as <jats:italic>β</jats:italic>‐sheet formation tends to lead to ill‐defined and unprocessable aggregates. This work reports a simple, rapid, and robust strategy to form well‐defined peptide <jats:italic>β</jats:italic>‐sheet‐assembled shells (i.e., hollow spheres) by employing surface‐initiated <jats:italic>N</jats:italic>‐carboxyanhydride ring‐opening polymerization under a highly efficient surface‐driven approach. The concept is demonstrated by the preparation of enzyme‐degradable rigid shell architectures composed of H‐bonded poly(L‐valine) (PVal) grafts with porous and sponge‐like surface morphology. The porous PVal‐shells exhibit a remarkable and unprecedented ability to non‐covalently entrap metal nanoparticles, proteins, drug molecules, and biorelevant polymers, which could potentially lead to a diverse range of biodegradable and functional platforms for applications ranging from therapeutic delivery to organic catalysis.</jats:p>
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Data source: Supporting information, http://onlinelibrary.wiley.com.access.library.unisa.edu.au/store/10.1002/adfm.201404091/asset/supinfo/adfm201404091-sup-0001-S1.pdf?v=1&s=3879323169d1dac917e01c5f139d54c0fb40aaee
Link to a related website: http://minerva-access.unimelb.edu.au/bitstream/11343/54981/1/OA_Wibowo_Functional-well-defined.pdf, Open Access via Unpaywall
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Copyright 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim