c-myb proto-oncogene is up-regulated in hypertrophic scars and correlates with increased collagen I
Date
2008
Authors
Kopecki, Z.
Adams, D.
Cowin, A.
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Journal article
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Wound Practice and Research, 2008; 16(3):132-137
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Kopecki Z, Adams D & Cowin AJ
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Abstract
Hypertrophic scar formation is a serious medical problem involving an excess fibro-proliferative response; it is particularly observed in burns patients and patients with a variety of diseases including keloids and scleroderma. Type I collagen is the major form of collagen produced in response to wounding and is involved in cutaneous fibrosis and scar formation. A recently discovered function of the well known c-myb proto-oncogene, previously reported to be involved in regulating cell growth and development, is its ability to regulate type I collagen protein production. Previously we have shown that c-myb plays an important role in wound repair, by regulating collagen synthesis and cellular proliferation and migration. Here we examine the involvement of c-myb in different human wound and scar tissues. Human tissue collected from hypertrophic scars, keloid scars, acute wounds and chronic venous leg ulcers were immunostained for c-myb and collagen I. Our results reveal a significant increase in c-myb protein levels in hypertrophic scars but not acute wounds, keloids or chronic ulcers. Interestingly, this increase in c-myb expression corresponded to the increased expression of collagen I in hypertrophic scars. These findings suggest that c-myb may be an important modulator of collagen synthesis in hypertrophic scar formation and may be important in wound fibrosis and scarring. Manipulation of c-myb levels may be of value in promoting improved wound healing and reducing scar formation.
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Copyright 2008 Cambridge Scholars Publishing