Cytokine receptors and their ligands
Date
2023
Authors
Shing, K.S.C.T.
Kan, W.L.
Nero, T.L.
Hercus, T.R.
Tvorogov, D.
Metcalfe, R.D.
Griffin, M.D.W.
De Weerd, N.A.
Guthridge, M.A.
Hertzog, P.J.
Editors
Bradshaw, R.
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Book chapter
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Source details - Title: Encyclopedia of Cell Biology, 2023 / Bradshaw, R. (ed./s), vol.4, pp.21-45
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Abstract
Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons and colony stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.
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Copyright 2022 Elsevier