Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials
Date
2018
Authors
Fuller, J.T.
Hartland, M.C.
Maloney, L.T.
Davison, K.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
British Journal of Sports Medicine, 2018; 52(20):1-11
Statement of Responsibility
Conference Name
Abstract
Objective: To systematically appraise and summarise meta-analyses investigating the effect of exercise compared with a control condition on health outcomes in cancer survivors.
Design: Umbrella review of intervention systematic reviews.
Data sources: Web of Science, Scopus, Cochrane Library, CINAHL and MEDLINE databases were searched using a predefined search strategy.
Eligibility criteria: Eligible meta-analyses compared health outcomes between cancer survivors participating in an exercise intervention and a control condition.Health outcomes were cardiovascular fitness, muscle strength, health-related quality of life, cancer-related fatigue and depression. Pooled effect estimates from each meta-analysis were quantified using standardised mean differences and considered trivial (<0.20),small (0.20–0.49), moderate (0.50–0.79) and large(≥0.80). Findings were summarised using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.
Results: There were 65 eligible articles that reported a total of 140 independent meta-analyses. 139/140meta-analyses suggested a beneficial effect of exercise. The beneficial effect was statistically significant in 104(75%) meta-analyses. Most effect sizes were moderate for cardiovascular fitness and muscle strength and small for cancer-related fatigue, health-related quality of life and depression. The quality of evidence was variable according to the GRADE scale, with most studies rated low or moderate quality. Median incidence of exercise related adverse events was 3.5%.
Conclusion: Exercise likely has an important role in helping to manage physical function, mental health, general well-being and quality of life in people undergoing and recovering from cancer and side effects of treatment.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2018 Article author (or their employer)