Development of New Antibiotics Based on Biotin Biology
| dc.contributor.advisor | Abell, Andrew | |
| dc.contributor.advisor | George, Jonathan | |
| dc.contributor.author | Lee, Kwang Jun | |
| dc.contributor.school | School of Physical Sciences | en |
| dc.date.issued | 2019 | |
| dc.description.abstract | PARTIAL ABSTRACT: Biotin is an essential vitamin that is required for growth and pathogenicity of bacteria. Biotin protein ligase (BPL) catalyses the ordered reaction of biotin and ATP to give biotinyl-5̕´-MP, which then activates a number of biotin dependent enzymes that are critical to cell survival. Dethiobiotin synthase (DTBS) is the sole enzyme responsible for catalysing a key step in biotin biosynthesis, namely the carboxylation of 7,8-diaminopelargonic acid (DAPA), closing the ureido ring to form dethiobiotin in a reaction requiring a nucleotide triphosphate. Research undertaken in this thesis highlights strategies to selectively inhibit Staphylococcus aureus biotin protein ligase (SaBPL) using 1,2,3-triazole and sulfonamide isosteres to replace the phosphoroanhydride linker found in biotinyl-5´-AMP. In addition, this thesis discusses the design and development of inhibitors targeting Mycobacterium tuberculosis dethiobiotin synthase (MtbDTBS). | en |
| dc.description.dissertation | Thesis (Ph.D.) -- University of Adelaide, School of Physical Sciences, 2019 | en |
| dc.identifier.uri | http://hdl.handle.net/2440/122310 | |
| dc.language.iso | en | en |
| dc.provenance | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals | en |
| dc.subject | Antibiotic | en |
| dc.subject | biotin protein ligase | en |
| dc.subject | dethiobiotin synthase | en |
| dc.subject | enzyme inhibitor | en |
| dc.title | Development of New Antibiotics Based on Biotin Biology | en |
| dc.type | Thesis | en |
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