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The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals

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dc.contributor.authorJohnston, C.H.
dc.contributor.authorWhittaker, A.L.
dc.contributor.authorFranklin, S.H.
dc.contributor.authorHutchinson, M.R.
dc.date.issued2022
dc.description.abstractCommunication between the central nervous system (CNS) and the immune system has gained much attention for its fundamental role in the development of chronic and pathological pain in humans and rodent models. Following peripheral nerve injury, neuroimmune signaling within the CNS plays an important role in the pathophysiological changes in pain sensitivity that lead to chronic pain. In production animals, routine husbandry procedures such as tail docking and castration, often involve some degree of inflammation and peripheral nerve injury and consequently may lead to chronic pain. Our understanding of chronic pain in animals is limited by the difficulty in measuring this pathological pain state. In light of this, we have reviewed the current understanding of chronic pain in production animals. We discuss our ability to measure pain and the implications this has on animal welfare and production outcomes. Further research into the neuroimmune interface in production animals will improve our fundamental understanding of chronic pain and better inform human clinical pain management and animal husbandry practices and interventions.
dc.description.statementofresponsibilityCharlotte H. Johnston, Alexandra L. Whittaker, Samantha H. Franklin, and Mark R. Hutchinson
dc.identifier.citationFrontiers in Neuroscience, 2022; 16:1-16
dc.identifier.doi10.3389/fnins.2022.887042
dc.identifier.issn1662-4548
dc.identifier.issn1662-453X
dc.identifier.orcidJohnston, C.H. [0000-0003-1049-9418]
dc.identifier.orcidWhittaker, A.L. [0000-0001-9011-8296]
dc.identifier.orcidFranklin, S.H. [0000-0002-6761-5371]
dc.identifier.orcidHutchinson, M.R. [0000-0003-2154-5950]
dc.identifier.urihttps://hdl.handle.net/2440/135645
dc.language.isoen
dc.publisherFrontiers Media SA
dc.relation.granthttp://purl.org/au-research/grants/arc/CE140100003
dc.relation.granthttp://purl.org/au-research/grants/arc/FT180100565
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1140072
dc.rightsCopyright © 2022 Johnston, Whittaker, Franklin and Hutchinson. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.source.urihttps://doi.org/10.3389/fnins.2022.887042
dc.subjectchronic pain; husbandry procedures; livestock; neuroimmune; animal welfare; neuropathic pain
dc.titleThe Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals
dc.typeJournal article
pubs.publication-statusPublished

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