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Role of microglia and toll-like receptor 4 in the pathophysiology of delirium

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dc.contributor.authorJalleh, R.
dc.contributor.authorKoh, K.
dc.contributor.authorChoi, B.
dc.contributor.authorLiu, E.
dc.contributor.authorMaddison, J.
dc.contributor.authorHutchinson, M.
dc.date.issued2012
dc.description.abstractDelirium is a serious medical condition that commonly afflicts elderly inpatients. This is especially common in the post-operative setting where it increases mortality, length of hospital stay and health care costs. The exact mechanisms involved in its pathogenesis remain uncertain and there is currently no effective pharmacological therapy for treatment or prevention of delirium. We hypothesize that microglia-mediated neuroinflammation via toll-like receptor 4 signalling is a significant contributor to post-operative delirium. Based on our proposed mechanism, three novel pharmacological therapies have been suggested to be effective to prevent or treat delirium. Curcumin, ibudilast and minocycline have been shown to interfere with various steps in the proinflammatory microglial activation intracellular signalling pathway, disrupting the subsequent neuroinflammatory cascade. We hypothesize that these drugs could be a novel pharmacotherapy that could significantly improve the outcome of post-operative delirious patients.
dc.description.statementofresponsibilityRyan Jalleh, Keith Koh, Boyoun Choi, Ebony Liu, John Maddison, Mark R. Hutchinson
dc.identifier.citationMedical Hypotheses, 2012; 79(6):735-739
dc.identifier.doi10.1016/j.mehy.2012.08.013
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.orcidJalleh, R. [0000-0003-4969-4771]
dc.identifier.orcidMaddison, J. [0000-0001-8692-8878]
dc.identifier.orcidHutchinson, M. [0000-0003-2154-5950]
dc.identifier.urihttp://hdl.handle.net/2440/75190
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.granthttp://purl.org/au-research/grants/arc/DP110100297
dc.rightsCopyright © 2012 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.mehy.2012.08.013
dc.subjectMicroglia
dc.subjectHumans
dc.subjectDelirium
dc.subjectModels, Theoretical
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectToll-Like Receptor 4
dc.titleRole of microglia and toll-like receptor 4 in the pathophysiology of delirium
dc.typeJournal article
pubs.publication-statusPublished

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