Evaluation of the role of pH in wound healing and development of buffered preparations to promote regeneration /
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(Published version)
Date
2022
Authors
Sim, Pivian
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thesis
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Abstract
This dissertation established pH as an important factor in enhancing wound healing. Altering wound microenvironment with low molarity acidic buffers at pH 4 increased proliferation and migration of skin cells in vitro. A time-dependent effect was also observed with once-every-second-day treatment significantly improved cell proliferation and migration in vitro. These findings were further proven in vivo, with pH 4 acidic buffers showing excellent wound recovery as early as 2-days post treatment with evidence of increased re-epithelialization, wound contracture, and upregulation of collagen levels. A hydrogel formulation was then developed using natural chitosan and citric acid buffer system, showing excellent anti-microbial activity and enhanced cell growth, presenting a potential wound management formulation for treating both infected and un-infected chronic wounds.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Pharmaceutical Science))--University of South Australia, 2022.
Provenance
Copyright 2022 Pivian Sim
Description
1 ethesis (xix, 137 pages) :
colour illustrations.
Includes bibliographical references.
colour illustrations.
Includes bibliographical references.
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506 0#$fstar $2Unrestricted online access