Elevated serum cytokine levels using cytometric bead arrays predict culture-positive infections in childhood oncology patients with febrile neutropenia

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dc.contributor.authorBadurdeen, S.
dc.contributor.authorHodge, G.
dc.contributor.authorOsborn, M.
dc.contributor.authorScott, J.
dc.contributor.authorSt John-Green, C.
dc.contributor.authorTapp, H.
dc.contributor.authorZola, H.
dc.contributor.authorRevesz, T.
dc.date.issued2012
dc.description.abstractNeutropenic patients with bacteraemia need prolonged intravenous antibiotic treatment. Using cytometric bead array technology, we show in children with febrile neutropenia that bacteraemia is associated with an elevation of at least 1 of 3 plasma cytokines plus C-reactive protein. The combination of interleukin (IL)-8, IL-6, IL-10, and C-reactive protein values above operator-defined cutoff levels identified 15 of 16 episodes of bacteraemia, making this a potentially useful technique in identifying high-risk patients who should not be discharged early from hospital. Furthermore, low risk of bacteraemia may be predicted by a combination of below threshold cytokines and negative clinical examination.
dc.description.statementofresponsibilityBadurdeen, Shiraz; Hodge, Greg; Osborn, Michael; Scott, Julius; St. John-Green, Celia; Tapp, Heather; Zola, Heddy; Revesz, Tamas
dc.identifier.citationJournal of Pediatric Hematology/Oncology, 2012; 34(1):E36-E38
dc.identifier.doi10.1097/MPH.0b013e3182193009
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.orcidOsborn, M. [0000-0002-1288-9930]
dc.identifier.orcidRevesz, T. [0000-0003-2501-0259]
dc.identifier.urihttp://hdl.handle.net/2440/76406
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rights© 2012 Lippincott Williams & Wilkins, Inc.
dc.source.urihttps://doi.org/10.1097/mph.0b013e3182193009
dc.subjectfebrile
dc.subjectneutropenia
dc.subjectcytokine
dc.subjectprediction
dc.subjectbacteraemia
dc.titleElevated serum cytokine levels using cytometric bead arrays predict culture-positive infections in childhood oncology patients with febrile neutropenia
dc.typeJournal article
pubs.publication-statusPublished

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