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Photocrosslinkable carboxylated polyvinyl alcohol nanocomposite hydrogels with enhanced compressive strength and cell adhesion

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dc.contributor.authorChen, X.
dc.contributor.authorZhang, M.
dc.contributor.authorZhu, D.
dc.contributor.authorZhang, J.
dc.contributor.authorShi, K.
dc.contributor.authorYang, H.
dc.contributor.authorGu, S.
dc.contributor.authorXiao, P.
dc.contributor.authorZhou, Y.
dc.date.issued2023
dc.descriptionData source: Supplementary information, https://doi.org/10.1016/j.eurpolymj.2023.112252
dc.description.abstractPolyvinyl alcohol (PVA) hydrogel is a kind of biomaterial with broad application prospects in the biomedical fields, but its poor mechanical properties and weak cell adhesion hinder its development. Herein, carboxylated PVA with acrylate groups (PVAGMACOOH) is synthesized, and consequently carboxylated PVA nanocomposite hydrogels are fabricated by UV-irradiating the mixture of PVAGMACOOH solution and nano-scale hydroxyapatite (HAP). The nanocomposite hydrogel can gel within several seconds under the UV light irradiation. Notably, it exhibits excellent compressive strength without fracture in the strain of more than 90%, while its tensile strength is 14.6 times of the pure PVA hydrogel without HAP, indicating energy dissipation mechanism by macromolecular chain creep and good load transferring from macromolecules to nanoparticles. Furthermore, the introduction of HAP significantly enhances cytocompatibility and cell adhesion of the hydrogel. The hydrogel would be a potential candidate for various biomedical applications.
dc.identifier.citationEuropean Polymer Journal, 2023; 196(112252):1-7
dc.identifier.doi10.1016/j.eurpolymj.2023.112252
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.urihttps://hdl.handle.net/11541.2/35002
dc.language.isoen
dc.publisherElsevier
dc.relation.fundingKnowledge Innovation Program of Wuhan-Basic Research 2022020801010246
dc.relation.fundingApplied Basic Research Program (Frontiers Research) of Wuhan Science and Technology Bureau 2022023988065191
dc.rightsCopyright 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.source.urihttps://doi.org/10.1016/j.eurpolymj.2023.112252
dc.subjectpolyvinyl alcohol
dc.subjectnanocomposite hydrogel
dc.subjectphotopolymerization
dc.subjectstrength
dc.subjectcell adhesion
dc.titlePhotocrosslinkable carboxylated polyvinyl alcohol nanocomposite hydrogels with enhanced compressive strength and cell adhesion
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12272804230001831 13272804220001831 Open Access Published Version
ror.mmsid9916776906301831

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