Parametric imaging of viscoelasticity using optical coherence elastography
Date
2015
Authors
Wijesinghe, P.
McLaughlin, R.
Sampson, D.
Kennedy, B.
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Journal article
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Physics in Medicine and Biology, 2015; 60(6):2293-2307
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Philip Wijesinghe, Robert A McLaughlin, David D Sampson and Brendan F Kennedy
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Abstract
We demonstrate imaging of soft tissue viscoelasticity using optical coherence elastography. Viscoelastic creep deformation is induced in tissue using step-like compressive loading and the resulting time-varying deformation is measured using phase-sensitive optical coherence tomography. From a series of co-located B-scans, we estimate the local strain rate as a function of time, and parameterize it using a four-parameter Kelvin-Voigt model of viscoelastic creep. The estimated viscoelastic strain and time constant are used to visualize viscoelastic creep in 2D, dual-parameter viscoelastograms. We demonstrate our technique on six silicone tissue-simulating phantoms spanning a range of viscoelastic parameters. As an example in soft tissue, we report viscoelastic contrast between muscle and connective tissue in fresh, ex vivo rat gastrocnemius muscle and mouse abdominal transection. Imaging viscoelastic creep deformation has the potential to provide complementary contrast to existing imaging modalities, and may provide greater insight into disease pathology.
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© 2015 Institute of Physics and Engineering in Medicine