Associations of circulating calcium and 25-hydroxyvitamin D with glucose metabolism in pregnancy: a cross-sectional study in European and south Asian women

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dc.contributor.authorWhitelaw, D.
dc.contributor.authorScally, A.
dc.contributor.authorTuffnell, D.
dc.contributor.authorDavies, T.
dc.contributor.authorFraser, W.
dc.contributor.authorBhopal, R.
dc.contributor.authorWright, J.
dc.contributor.authorLawlor, D.
dc.date.issued2014
dc.description.abstractVitamin D deficiency is thought to impair insulin action and glucose metabolism; however, previous studies have not examined ethnic differences or the influence of calcium and parathyroid hormone. We investigated this in a cohort of predominantly white European and south Asian women during pregnancy.In this cross-sectional study from an urban population in northern England (53.8°N), 1467 women were recruited when undergoing glucose tolerance testing (75 g oral glucose tolerance test) at 26 weeks' gestation.Gestational diabetes mellitus (GDM) was diagnosed in 137 women (9.3%). Median 25-hydroxyvitamin D concentration for the study population was 9.3 ng/mL (interquartile range 5.2, 16.9) and was higher in European [15.2 ng/mL (10.7, 23.5)] than in south Asian women [5.9 ng/mL (3.9, 9.4), P < .001]. After appropriate adjustment for confounders, 25-hydroxyvitamin D showed a weak inverse association with fasting plasma glucose (FPG; mean difference 1.0% per 1 SD; the ratio of geometric means (RGM) 0.99, 95% confidence interval (CI) 0.98, 1.00), and PTH was weakly associated with FPG (RGM 1.01, 95% CI 1.00, 1.02), but neither was associated with fasting insulin, postchallenge glucose, or GDM. Serum calcium (albumin adjusted) was strongly associated with fasting insulin (RGM 1.06; 95% CI 1.03, 1.08), postchallenge glucose (RGM 1.03, 95% CI 1.01, 1.04), and GDM (odds ratio 1.33, 95% CI 1.06, 1.66) but not with FPG. Associations were similar in European and south Asian women.These findings do not indicate any important association between vitamin D status and glucose tolerance in pregnancy. Relationships between circulating calcium and glucose metabolism warrant further investigation.
dc.description.statementofresponsibilityDonald C. Whitelaw, Andrew J. Scally, Derek J. Tuffnell, T. Jeffrey Davies, William D. Fraser, Raj S. Bhopal, John Wright, Debbie A. Lawlor
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism (JCEM), 2014; 99(3):938-946
dc.identifier.doi10.1210/jc.2013-2896
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.orcidLawlor, D. [0000-0002-6793-2262]
dc.identifier.urihttp://hdl.handle.net/2440/112034
dc.language.isoen
dc.publisherEndocrine Society
dc.rights© 2014 by The Endocrine Society
dc.source.urihttps://doi.org/10.1210/jc.2013-2896
dc.subjectHumans
dc.subjectDiabetes, Gestational
dc.subjectVitamin D Deficiency
dc.subjectCalcium
dc.subjectGlucose
dc.subjectBlood Glucose
dc.subjectVitamin D
dc.subjectGlucose Tolerance Test
dc.subjectPrevalence
dc.subjectCross-Sectional Studies
dc.subjectPregnancy
dc.subjectAdult
dc.subjectAsian Continental Ancestry Group
dc.subjectEuropean Continental Ancestry Group
dc.subjectEngland
dc.subjectFemale
dc.subjectYoung Adult
dc.titleAssociations of circulating calcium and 25-hydroxyvitamin D with glucose metabolism in pregnancy: a cross-sectional study in European and south Asian women
dc.typeJournal article
pubs.publication-statusPublished

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