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Evaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases

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dc.contributor.authorStewart, C.J.R.
dc.contributor.authorAmanuel, B.
dc.contributor.authorDe Kock, L.
dc.contributor.authorApellaniz Ruiz, M.
dc.contributor.authorCarrello, A.
dc.contributor.authorGiardina, T.
dc.contributor.authorGrieu Iacopetta, F.
dc.contributor.authorThomas, M.A.
dc.contributor.authorFoulkes, W.D.
dc.date.issued2020
dc.description.abstractMolecular profiling was performed in 50 problematic ovarian sex cord-stromal tumours (SCSTs) most of which were seen in consultation. Following analysis, 17 were classified as adult granulosa cell tumour (AGCT), 16 of which showed a FOXL2 sequence variant (mutation); the initial favoured diagnosis in five of the cases was benign thecoma/fibrothecoma. Thirteen tumours ultimately classified as cellular fibroma or thecoma were FOXL2 sequence variant negative which was helpful in excluding AGCT. All six Sertoli-Leydig cell tumours (SLCTs) demonstrated DICER1 'hot spot' sequence variants, and one case each of AGCT and SLCT showed high grade histological transformation associated with a concurrent TP53 sequence variant. All eight unclassified SCSTs were negative for FOXL2 mutations and the six tested cases were DICER1 wild type; however, three tumours demonstrated MET, CTNNB1 or TP53 sequence variants. Four cases were classified as juvenile granulosa cell tumour, and one of these harboured a GNAS sequence variant. The single gynandroblastoma and microcystic stromal tumours in the series demonstrated FOXL2 and CTNNB1 alterations, respectively. In summary, molecular analysis aids in accurate classification of challenging ovarian SCSTs and sometimes leads to revision of the favoured provisional diagnosis. TP53 sequence variants may be associated with dedifferentiation in both SLCTs and AGCTs.
dc.identifier.citationPathology, 2020; 52(6):686-693
dc.identifier.doi10.1016/j.pathol.2020.06.008
dc.identifier.issn0031-3025
dc.identifier.issn1465-3931
dc.identifier.urihttps://hdl.handle.net/11541.2/43267
dc.language.isoen
dc.publisherElsevier
dc.relation.fundingCanadian Institutes of Health Research Foundation CIHR FDN 148390
dc.rightsCopyright 2020 oyal College of Pathologists of Australasia
dc.source.urihttps://doi.org/10.1016/j.pathol.2020.06.008
dc.subjectovary
dc.subjectsex cord-stromal tumour
dc.subjectmolecular
dc.subjectdicer1
dc.subjectfoxl2
dc.subjectdiagnostic
dc.subjecttp53
dc.titleEvaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916975548301831

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