Unexplained infertility: is it over-diagnosed and over-treated?

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dc.contributor.authorMol, B.W.
dc.contributor.authorTjon-Kon-Fat, R.
dc.contributor.authorKamphuis, E.
dc.contributor.authorvan Wely, M.
dc.date.issued2018
dc.description.abstractUnexplained infertility is defined as the absence of conception despite 12 months of unprotected intercourse, not explained by anovulation, poor sperm quality, tubal pathology or any known cause of infertility. The two most applied treatments for unexplained infertility are intra-uterine insemination and in vitro fertilisation. As these treatments do not target a specific mechanism but rather increase the probability of conception as compared to natural conception chances, they should be weighed against the prognosis of natural conception. The use of prognostic models could facilitate in identifying who benefits from treatment and who can delay treatment for 6 months, thus aiming for natural conception. This is important, as treatments can have side effects for the woman and her offspring, and their cost may jeopardise access to care.
dc.description.statementofresponsibilityBen W. Mol, Raissa Tjon-Kon-Fat, Esmé Kamphuis, Madelon van Wely
dc.identifier.citationBest Practice and Research: Clinical Obstetrics and Gynaecology, 2018; 53:20-29
dc.identifier.doi10.1016/j.bpobgyn.2018.09.006
dc.identifier.issn1521-6934
dc.identifier.issn1532-1932
dc.identifier.orcidMol, B.W. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.urihttp://hdl.handle.net/2440/117923
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1082548
dc.rights© 2018 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.bpobgyn.2018.09.006
dc.subjectUnexplained infertility; intra-uterine insemination; in vitro fertilisation; prognosis
dc.titleUnexplained infertility: is it over-diagnosed and over-treated?
dc.typeJournal article
pubs.publication-statusPublished

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