Sensory transmission in the gastrointestinal tract

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dc.contributor.authorBlackshaw, L.
dc.contributor.authorBrookes, S.
dc.contributor.authorGrundy, D.
dc.contributor.authorSchemann, M.
dc.date.issued2007
dc.descriptionThe definitive version is available at www.blackwell-synergy.com
dc.description.abstractThe gastrointestinal (GI) tract must balance ostensibly opposite functions. On the one hand, it must undertake the process of digestion and absorption of nutrients. At the same time, the GI tract must protect itself from potential harmful antigenic and pathogenic material. Central to these processes is the ability to ‘sense’ the mechanical and chemical environment in the gut wall and lumen in order to orchestrate the appropriate response that facilitates nutrient assimilation or the rapid expulsion through diarrhoea and/or vomiting. In this respect, the GI tract is richly endowed with sensory elements that monitor the gut environment. Enteric neurones provide one source of such sensory innervation and are responsible for the ability of the decentralized gut to perform complex reflex functions. Extrinsic afferents not only contribute to this reflex control, but also contribute to homeostatic mechanisms and can give rise to sensations, under certain circumstances. The enteric and extrinsic sensory mechanisms share a number of common features but also some remarkably different properties. The purpose of this review is to summarize current views on sensory processing within both the enteric and extrinsic innervation and to specifically address the pharmacology of nociceptive extrinsic sensory pathways.
dc.description.statementofresponsibilityL. A. Blackshaw, S. J. H. Brookes, D. Grundy & M. Schemann
dc.identifier.citationNeurogastroenterology and Motility, 2007; 19 Suppl.(1):1-19
dc.identifier.doi10.1111/j.1365-2982.2006.00871.x
dc.identifier.issn1350-1925
dc.identifier.issn1365-2982
dc.identifier.orcidBlackshaw, L. [0000-0003-1565-0850]
dc.identifier.urihttp://hdl.handle.net/2440/44828
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.source.urihttps://doi.org/10.1111/j.1365-2982.2006.00871.x
dc.subjectGastrointestinal Tract
dc.subjectVisceral Afferents
dc.subjectEnteric Nervous System
dc.subjectMechanoreceptors
dc.subjectAnimals
dc.subjectHumans
dc.subjectMechanotransduction, Cellular
dc.titleSensory transmission in the gastrointestinal tract
dc.typeJournal article
pubs.publication-statusPublished

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