Interaction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib

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dc.contributor.authorEadie, L.
dc.contributor.authorHughes, T.
dc.contributor.authorWhite, D.
dc.date.issued2014
dc.description.abstractThe efflux transporters adenosine triphosphate (ATP)-binding cassette (ABC)B1 and ABCG2 have been demonstrated to interact with the tyrosine kinase inhibitors (TKIs) imatinib, nilotinib, and dasatinib. However, although some studies conclude that TKIs are substrates of one or both transporters, other studies demonstrate only an inhibitory function. This variation is probably due to differences in the concentration of TKIs assayed and the experimental systems used. This article examines the evidence for clinically relevant interactions between three currently approved TKIs and ABCB1/ABCG2.
dc.description.statementofresponsibilityL N Eadie, T P Hughes and D L White
dc.identifier.citationClinical Pharmacology and Therapeutics, 2014; 95(3):294-306
dc.identifier.doi10.1038/clpt.2013.208
dc.identifier.issn0009-9236
dc.identifier.issn1532-6535
dc.identifier.orcidEadie, L. [0000-0003-1912-7602]
dc.identifier.orcidHughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509]
dc.identifier.orcidWhite, D. [0000-0003-4844-333X]
dc.identifier.urihttp://hdl.handle.net/2440/86734
dc.language.isoen
dc.publisherMosby
dc.rights© 2014 American Society for Clinical Pharmacology and Therapeutics
dc.source.urihttps://doi.org/10.1038/clpt.2013.208
dc.subjectAnimals
dc.subjectHumans
dc.subjectBenzamides
dc.subjectPiperazines
dc.subjectPyrimidines
dc.subjectThiazoles
dc.subjectATP-Binding Cassette Transporters
dc.subjectNeoplasm Proteins
dc.subjectEnzyme Inhibitors
dc.subjectProtein-Tyrosine Kinases
dc.subjectImatinib Mesylate
dc.subjectDasatinib
dc.subjectATP Binding Cassette Transporter, Subfamily G, Member 2
dc.subjectATP Binding Cassette Transporter, Subfamily B
dc.subjectATP Binding Cassette Transporter, Subfamily B, Member 1
dc.titleInteraction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib
dc.typeJournal article
pubs.publication-statusPublished

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