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Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia

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dc.contributor.authorRudkin, A.
dc.contributor.authorMuecke, J.
dc.date.issued2011
dc.description.abstractAim: To report the outcome of treatment of localised non-invasive ocular surface squamous neoplasia (OSSN) where topical 5-fluorouracil (5-FU 1%) is used as an adjuvant to surgical excision. Methods: The study was a prospective non-comparative interventional case series. 55 cases of primary localised OSSN and 10 cases of recurrent localised OSSN were treated with excision, cryotherapy and adjuvant 5-FU 1%. In all cases, irrespective of the involvement of surgical margins, a single cycle of 5-FU 1% was administered, four times a day for 2 weeks continuously. The main outcome measures were (1) recurrence and (2) complications related to adjuvant topical chemotherapy. Individuals were reviewed for a minimum of 12 months. Results: There was a single case of recurrence (1.5%). 57% of patients had short-term complications secondary to 5-FU 1%, most frequently lid toxicity (49%), followed by superficial keratitis, epiphora and corneal epithelial defects. Four patients were unable to complete the course of 5-FU 1% because of local toxicity. Conclusions: The management of localised non-invasive OSSN with adjuvant 5-FU 1% was associated with a low rate of local recurrence. Although 5-FU 1% frequently results in short-term complications, most commonly lid toxicity, a full course is usually tolerated. Serious complications appear uncommon in the treatment of localised disease.
dc.description.statementofresponsibilityAdam K Rudkin, James S Muecke
dc.identifier.citationBritish Journal of Ophthalmology, 2011; 95(7):947-950
dc.identifier.doi10.1136/bjo.2010.186171
dc.identifier.issn0007-1161
dc.identifier.issn1468-2079
dc.identifier.orcidRudkin, A. [0000-0003-2508-8574]
dc.identifier.urihttp://hdl.handle.net/2440/68501
dc.language.isoen
dc.publisherBritish Med Journal Publ Group
dc.source.urihttps://doi.org/10.1136/bjo.2010.186171
dc.subjectHumans
dc.subjectNeoplasms, Squamous Cell
dc.subjectEye Neoplasms
dc.subjectNeoplasm Recurrence, Local
dc.subjectFluorouracil
dc.subjectAntineoplastic Agents
dc.subjectTreatment Outcome
dc.subjectChemotherapy, Adjuvant
dc.subjectProspective Studies
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectVision, Ocular
dc.titleAdjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia
dc.typeJournal article
pubs.publication-statusPublished

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