Results of a standardised regimen for multidrug-resistant tuberculosis in Bangladesh
| dc.contributor.author | Van Deun, A. | |
| dc.contributor.author | Salim, M. | |
| dc.contributor.author | Das, A. | |
| dc.contributor.author | Bastian, I. | |
| dc.contributor.author | Portaels, F. | |
| dc.date.issued | 2004 | |
| dc.description.abstract | SETTING: Individualised regimens based on drug susceptibility test results, generally used to treat multidrug-resistant tuberculosis (MDR-TB), require often unavailable expertise and resources. OBJECTIVE: To evaluate a standardised regimen based on the susceptibility profiles of locally prevalent MDR-TB strains. DESIGN: The activities of a successful DOTS programme in Bangladesh were complemented by offering treatment with a standardised 21-month regimen to patients with laboratory-confirmed MDR-TB disease. The regimen contained kanamycin, ofloxacin, prothionamide, pyrazinamide, ethambutol, isoniazid and clofazimine. Clinical and bacteriological progress was monitored quarterly until treatment completion, then 6 monthly for 2 years. RESULTS: The status at the end of treatment of this cohort of 58 documented MDR-TB patients was as follows: eight (14%) deaths, seven (12%) defaults, three (5%) failures and 40 (69%) cures. One bacteriologically-confirmed relapse was recognised. Frequent and sometimes serious side effects proved to be the main problem, suggesting the need for a better tolerated but equally effective regimen. CONCLUSION: A standardised approach may provide a reasonable alternative to individualised treatment of MDR-TB in resource-poor settings. However, DOTS-plus programmes in resource-poor settings may confront significant difficulties in the enrolment, diagnosis and management of MDR-TB patients. | |
| dc.description.statementofresponsibility | A. Van Deun, M. A. Hamid Salim, A. P. Kumar Das, I. Bastian, F. Portaels | |
| dc.description.uri | http://www.ncbi.nlm.nih.gov/pubmed/15137531 | |
| dc.identifier.citation | International Journal of Tuberculosis and Lung Disease, 2004; 8(5):560-567 | |
| dc.identifier.issn | 1027-3719 | |
| dc.identifier.issn | 1815-7920 | |
| dc.identifier.uri | http://hdl.handle.net/2440/55665 | |
| dc.language.iso | en | |
| dc.publisher | Int Union Against Tuberculosis Lung Disease (i U A T L D) | |
| dc.subject | multi-drug resistance | |
| dc.subject | treatment | |
| dc.subject | control | |
| dc.subject | tuberculosis | |
| dc.title | Results of a standardised regimen for multidrug-resistant tuberculosis in Bangladesh | |
| dc.type | Journal article | |
| pubs.publication-status | Published |