The lymphatic vasculature: development and role in shaping immunity

Simple item page
dc.contributor.authorBetterman, K.L.
dc.contributor.authorHarvey, N.L.
dc.date.issued2016
dc.description.abstractThe lymphatic vasculature is an integral component of the immune system. Lymphatic vessels are a key highway via which immune cells are trafficked, serving not simply as a passive route of transport, but to actively shape and coordinate immune responses. Reciprocally, immune cells provide signals that impact the growth, development, and activity of the lymphatic vasculature. In addition to immune cell trafficking, lymphatic vessels are crucial for fluid homeostasis and lipid absorption. The field of lymphatic vascular research is rapidly expanding, fuelled by rapidly advancing technology that has enabled the manipulation and imaging of lymphatic vessels, together with an increasing recognition of the involvement of lymphatic vessels in a myriad of human pathologies. In this review we provide an overview of the genetic pathways and cellular processes important for development and maturation of the lymphatic vasculature, discuss recent work revealing important roles for the lymphatic vasculature in directing immune cell traffic and coordinating immune responses and highlight the involvement of lymphatic vessels in a range of pathological settings.
dc.description.statementofresponsibilityKelly L. Betterman, Natasha L. Harvey
dc.identifier.citationImmunological Reviews, 2016; 271(1):276-292
dc.identifier.doi10.1111/imr.12413
dc.identifier.issn0105-2896
dc.identifier.issn1600-065X
dc.identifier.orcidHarvey, N.L. [0000-0001-9839-8966]
dc.identifier.urihttp://hdl.handle.net/2440/100254
dc.language.isoen
dc.publisherWiley
dc.relation.grantNHMRC
dc.relation.grantARC
dc.rights© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
dc.source.urihttps://doi.org/10.1111/imr.12413
dc.subjectLymphatic vessels; lymph nodes; immunity; development
dc.titleThe lymphatic vasculature: development and role in shaping immunity
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications