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Structurally tuned benzo[h]chromene derivative as Pb2+ selective 'turn-on' fluorescence sensor for living cell imaging

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dc.contributor.authorSinha, S.
dc.contributor.authorKoner, R.R.
dc.contributor.authorKumar, S.
dc.contributor.authorMathew, J.
dc.contributor.authorRoy, A.
dc.contributor.authorMukhopadhyay, S.K.
dc.contributor.authorNandi, C.K.
dc.contributor.authorGhosh, S.
dc.date.issued2013
dc.descriptionData source: Supporting information, https://doi.org/10.1016/j.jlumin.2013.05.012
dc.description.abstractA benzo[h]chromene derivative, 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile 1, has been utilized as ‘Turn On’ fluorescence chemosensor for the selective detection of Pb2+. The title compound 1 was synthesized in one step using a multicomponent condensation reaction (MCR), and characterized using various spectroscopic techniques. The selectivity was tested over a range of 17 different metal and non-metal ions. Compound 1 was found to be weak fluorescent (Φ1=0.06) because of photoinduced electron transfer (PET). The presence of 2 equiv of Pb2+ showed a significant increase in fluorescence quantum yield (Φ1−Pb2+=0.132). A change in weak blue emission of 1 to a glowing green emission along with a prominent red shift (26 nm) in emission band was observed upon addition of Pb2+ to a methanolic solution of 1. The complexation of 1 with Pb2+ was proved by mass spectroscopy and NMR studies. Some of our experimental findings have been supported by theoretical studies. Compound 1 was found to be easily permeable to living cells without causing any harm and ultimately was used to detect effectively Pb2+ in living system.
dc.identifier.citationJournal of Luminescence, 2013; 143:355-360
dc.identifier.doi10.1016/j.jlumin.2013.05.012
dc.identifier.issn0022-2313
dc.identifier.urihttps://hdl.handle.net/11541.2/119838
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright 2013 Elsevier B.V.
dc.source.urihttps://doi.org/10.1016/j.jlumin.2013.05.012
dc.subjectBenzo[h]chromene
dc.subjectFluorescence chemosensor
dc.subjectSelective detection
dc.subjectCell imaging
dc.titleStructurally tuned benzo[h]chromene derivative as Pb2+ selective 'turn-on' fluorescence sensor for living cell imaging
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915989385401831

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