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Crab shell extract improves sperm parameters and antioxidant status in testes of diabetic rats

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dc.contributor.authorGhanbari, E.
dc.contributor.authorKhazaei, M.R.
dc.contributor.authorAhangar, P.
dc.contributor.authorKhazaei, M.
dc.date.issued2019
dc.description.abstractCrab shell (CS), which contains antioxidant compounds, has been used as a promising nutritional and medical compound in traditional medicine. Oxidative stress plays a critical role in the development of diabetes. This study aims to investigate the effects of CS extract (CSE) on sperm parameters, antioxidant status, and histopathology changes of testes in diabetic rats. In this experimental study, 40 Wistar male rats were investigated in five groups (n = 8/group): diabetic rats treated with different CS concentrations (i.e., 100, 200, and 400 mg/kg), diabetic group, and nondiabetic control. To induce diabetes, a single dose (60 mg/kg) of streptozotocin (STZ) was injected intraperitoneally; three days later, treatment with CSE was begun and conducted for 14 days. The fasting blood glucose, testes weight, and viability, number, and motility of sperm were assessed. In addition, the levels of ferric reducing antioxidant power (FRAP) and nitric oxide (NO) were estimated in the testes. Testes were examined using histological analysis. The results of this study revealed that sperm number, motility, and serum testosterone levels of CSE-treated diabetic rats increased significantly (p = .000) compared with the untreated diabetic group in a dose-depended manner while the number of immotile sperm decreased significantly (p = .017). CS also reduced the testicular level of nitric oxide and fasting blood glucose; however, it led to significant growth in the FRAP levels of testes (p = .002). Our results suggest that CSE improves sperm parameters and protects the testicular tissue against the oxidative stress damage induced by diabetes.
dc.identifier.citationJournal of Dietary Supplements, 2019; 16(2):215-226
dc.identifier.doi10.1080/19390211.2018.1448923
dc.identifier.issn1939-0211
dc.identifier.issn1939-022X
dc.identifier.urihttps://hdl.handle.net/11541.2/131743
dc.language.isoen
dc.publisherTaylor and Francis
dc.rightsCopyright 2018 Taylor and Francis Group, LLC
dc.source.urihttps://doi.org/10.1080/19390211.2018.1448923
dc.subjectcrab shell
dc.subjectdiabetes
dc.subjectrats
dc.subjectsperm
dc.subjecttestes
dc.titleCrab shell extract improves sperm parameters and antioxidant status in testes of diabetic rats
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916188202301831

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