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Metformin in gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age

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dc.contributor.authorRowan, J.
dc.contributor.authorRush, E.
dc.contributor.authorObolonkin, V.
dc.contributor.authorBattin, M.
dc.contributor.authorWouldes, T.
dc.contributor.authorHague, W.
dc.date.issued2011
dc.description.abstractOBJECTIVE: In women with gestational diabetes mellitus, who were randomized to metformin or insulin treatment, pregnancy outcomes were similar (Metformin in Gestational diabetes [MiG] trial). Metformin crosses the placenta, so it is important to assess potential effects on growth of the children. RESEARCH DESIGN AND METHODS: In Auckland, New Zealand, and Adelaide, Australia, women who had participated in the MiG trial were reviewed when their children were 2 years old. Body composition was measured in 154 and 164 children whose mothers had been randomized to metformin and insulin, respectively. Children were assessed with anthropometry, bioimpedance, and dual energy X-ray absorptiometry (DEXA), using standard methods. RESULTS: The children were similar for baseline maternal characteristics and pregnancy outcomes. In the metformin group, compared with the insulin group, children had larger mid-upper arm circumferences (17.2 6 1.5 vs. 16.7 6 1.5 cm; P = 0.002) and subscapular (6.3 6 1.9 vs. 6.0 6 1.7 mm; P = 0.02) and biceps skinfolds (6.03 6 1.9 vs. 5.6 6 1.7 mm; P = 0.04). Total fat mass and percentage body fat assessed by bioimpedance (n = 221) and DEXA (n = 114) were not different. CONCLUSIONS: Children exposed to metformin had larger measures of subcutaneous fat, but overall body fat was the same as in children whose mothers were treated with insulin alone. Further follow-up is required to examine whether these findings persist into later life and whether children exposed to metformin will develop less visceral fat and be more insulin sensitive. If so, this would have significant implications for the current pandemic of diabetes.
dc.description.statementofresponsibilityJanet A. Rowan, Elaine C. Rush, Victor Obolonkin, Malcolm Battin, Trecia Wouldes and William M. Hague
dc.identifier.citationDiabetes Care, 2011; 34(10):2279-2284
dc.identifier.doi10.2337/dc11-0660
dc.identifier.issn0149-5992
dc.identifier.issn1935-5548
dc.identifier.orcidHague, W. [0000-0002-5355-2955]
dc.identifier.urihttp://hdl.handle.net/2440/71758
dc.language.isoen
dc.publisherAmer Diabetes Assoc
dc.rights© 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
dc.source.urihttps://doi.org/10.2337/dc11-0660
dc.subjectHumans
dc.subjectDiabetes, Gestational
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectMetformin
dc.subjectInsulin
dc.subjectHypoglycemic Agents
dc.subjectAbsorptiometry, Photon
dc.subjectAnthropometry
dc.subjectFollow-Up Studies
dc.subjectBody Composition
dc.subjectPregnancy
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.titleMetformin in gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age
dc.typeJournal article
pubs.publication-statusPublished

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