Tumor necrosis factor priming of peripheral blood neutrophils from rheumatoid arthritis patients

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dc.contributor.authorKowanko, I.
dc.contributor.authorFerrante, A.
dc.contributor.authorClemente, G.
dc.contributor.authorYoussef, P.
dc.contributor.authorSmith, M.
dc.date.issued1996
dc.description.abstractRecently it was shown that tumor necrosis factor-agr (TNF) receptors on neutrophils may be down-regulated after stimulation with proinflammatory mediators. Since in rheumatoid arthritis neutrophils are likely to encounter these mediators in the circulation, we tested the hypothesis that rheumatoid arthritis neutrophil TNF receptors are down-regulated. Peripheral blood neutrophils from patients with rheumatoid arthritis and healthy subjects were compared with respect to their TNF binding activity and ability to be primed by TNF. There were no differences between rheumatoid arthritis and control neutrophils in receptor-mediated TNF binding, superoxide release in response to agonist, and TNF priming of this respiratory burst or in the ability to degrade cartilagein vitro and TNF priming for increased cartilage damage. It is evident that rheumatoid arthritis blood neutrophils retain the ability to bind TNF and can be primed by TNF for increased oxygen radical production and augmented cartilage damage. These findings further implicate the role of neutrophils in the pathogenesis of arthritis.
dc.description.statementofresponsibilityI. C. Kowanko, A. Ferrante, G. Clemente, P. P. Youssef and M. Smith
dc.identifier.citationJournal of Clinical Immunology, 1996; 16(4):216-221
dc.identifier.doi10.1007/BF01541227
dc.identifier.issn0271-9142
dc.identifier.issn1573-2592
dc.identifier.orcidFerrante, A. [0000-0002-2581-6407]
dc.identifier.urihttp://hdl.handle.net/2440/14695
dc.language.isoen
dc.publisherPLENUM PUBL CORP
dc.rights© 1996 Plenum Publishing Corporation
dc.source.urihttps://doi.org/10.1007/bf01541227
dc.subjectTumor necrosis factor
dc.subjectreceptor
dc.subjectneutrophil
dc.subjectpriming
dc.subjectrheumatoid arthritis
dc.subjectsuperoxide
dc.subjectrespiratory burst
dc.subjectcartilage injury
dc.subjectpathogenesis
dc.titleTumor necrosis factor priming of peripheral blood neutrophils from rheumatoid arthritis patients
dc.typeJournal article
pubs.publication-statusPublished

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