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A frailty index based on deficit accumulation quantifies mortality risk in humans and in mice

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dc.contributor.authorRockwood, K.
dc.contributor.authorBlodgett, J.M.
dc.contributor.authorTheou, O.
dc.contributor.authorSun, M.H.
dc.contributor.authorFeridooni, H.A.
dc.contributor.authorMitnitski, A.
dc.contributor.authorRose, R.A.
dc.contributor.authorGodin, J.
dc.contributor.authorGregson, E.
dc.contributor.authorHowlett, S.E.
dc.date.issued2017
dc.description.abstractAlthough many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the impact of ageing requires some useful means of measuring variability in health in animals of the same age. In humans, this variability has been quantified by counting age-related health deficits in a frailty index. Here we show the results of extending that approach to mice. Across the life course, many important features of deficit accumulation are present in both species. These include gradual rates of deficit accumulation (slope = 0.029 in humans; 0.036 in mice), a submaximal limit (0.54 in humans; 0.44 in mice), and a strong relationship to mortality (1.05 [1.04-1.05] in humans; 1.15 [1.12-1.18] in mice). Quantifying deficit accumulation in individual mice provides a powerful new tool that can facilitate translation of research on ageing, including in relation to disease.
dc.description.statementofresponsibilityK. Rockwood, J. M. Blodgett, O. Theou, M. H. Sun, H. A. Feridooni, A. Mitnitski, R. A. Rose, J. Godin, E. Gregson and S. E. Howlett
dc.identifier.citationScientific Reports, 2017; 7(1):43068-1-43068-10
dc.identifier.doi10.1038/srep43068
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.orcidTheou, O. [0000-0001-6460-782X]
dc.identifier.urihttp://hdl.handle.net/2440/123140
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1038/srep43068
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectAge Factors
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectFrailty
dc.titleA frailty index based on deficit accumulation quantifies mortality risk in humans and in mice
dc.typeJournal article
pubs.publication-statusPublished

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