Preparation and properties of a silybin-phospholipid complex
Date
2008
Authors
Song, Y.
Zhuang, J.
Guo, J.
Xiao, Y.
Ping, Q.
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Journal article
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Die Pharmazie, 2008; 63(1):35-42
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Abstract
Due to its poor solubility in water and oil, silybin is hardly absorbed orally and cannot be dissolved directly for parenteral preparations. In this study, a silybin-phospholipid complex was prepared by single-factor design and orthogonal experimental design. Lipophilicity was improved to a large extent, which was determined by solubility experiments and oil/water partition studies. Various methods were used to confirm the formation and explore the properties of the silybin-phospholipid complex, such as UV, IR, ATR, CNMR, XRD,DSC, SEM and TEM. The structure of the phytosome when the complex was dispersed in aqueous solution is suggested.
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Copyright 2008 Avoxa - Mediengruppe Deutscher Apotheker GmbH