Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource Study

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dc.contributor.authorFox, E.
dc.contributor.authorYoung, J.
dc.contributor.authorLi, Y.
dc.contributor.authorDreisbach, A.
dc.contributor.authorKeating, B.
dc.contributor.authorMusani, S.
dc.contributor.authorLiu, K.
dc.contributor.authorMorrison, A.
dc.contributor.authorGanesh, S.
dc.contributor.authorKutlar, A.
dc.contributor.authorRamachandran, V.
dc.contributor.authorPolak, J.
dc.contributor.authorFabsitz, R.
dc.contributor.authorDries, D.
dc.contributor.authorFarlow, D.
dc.contributor.authorRedline, S.
dc.contributor.authorAdeyemo, A.
dc.contributor.authorHirschorn, J.
dc.contributor.authorSun, Y.
dc.contributor.authorWyatt, S.
dc.contributor.authoret al.
dc.date.issued2011
dc.descriptionLyle J. Palmer is a member of ICBP-GWAS (nternational Consortium for Blood Pressure Genome-wide Association Studies)
dc.description.abstractThe prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.
dc.description.statementofresponsibilityErvin R. Fox, J. Hunter Young, Yali Li, Albert W. Dreisbach, Brendan J. Keating, Solomon K. Musani, Kiang Liu, Alanna C. Morrison, Santhi Ganesh, Abdullah Kutlar, Vasan S. Ramachandran, Josef F. Polak, Richard R. Fabsitz, Daniel L. Dries, Deborah N. Farlow, Susan Redline, AdebowaleAdeyemo, Joel N. Hirschorn, Yan V. Sun, Sharon B. Wyatt, Alan D. Penman, Walter Palmas, Jerome I. Rotter, Raymond R. Townsend, Ayo P. Doumatey, Bamidele O. Tayo, Thomas H. Mosley Jr, Helen N. Lyon, Sun J. Kang, Charles N. Rotimi, Richard S. Cooper, Nora Franceschini, J. David Curb, Lisa W. Martin, Charles B. Eaton, Sharon L.R. Kardia, Herman A. Taylor, Mark J. Caulfield, Georg B. Ehret, Toby Johnson, The International Consortium for Blood Pressure Genome-wide Association Studies, ICBP-GWAS, Aravinda Chakravarti, Xiaofeng Zhu, and Daniel Levy
dc.identifier.citationHuman Molecular Genetics, 2011; 20(11):2273-2284
dc.identifier.doi10.1093/hmg/ddr092
dc.identifier.issn0964-6906
dc.identifier.issn1460-2083
dc.identifier.urihttp://hdl.handle.net/2440/88214
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.rights© The Author 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1093/hmg/ddr092
dc.subjectInternational Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS)
dc.subjectHumans
dc.subjectHypertension
dc.subjectCohort Studies
dc.subjectBlood Pressure
dc.subjectDiastole
dc.subjectSystole
dc.subjectGenotype
dc.subjectPhenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectWhite People
dc.subjectBlack or African American
dc.titleAssociation of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource Study
dc.typeJournal article
pubs.publication-statusPublished

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