Nitric oxide-releasing porous silicon nanoparticles
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(Published version)
Date
2014
Authors
Hasanzadeh Kafshgari, M.
Cavallaro, A.A.
Delalat, B.
Harding, F.J.
McInnes, S.J.P.
Makila, E.
Salonen, J.
Vasilev, K.A.
Voelcker, N.
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Nanoscale Research Letters, 2014; 9(article no. 333):1-9
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Abstract
In this study, the ability of porous silicon nanoparticles (PSi NPs) to entrap and deliver nitric oxide (NO) as an effective antibacterial agent is tested against different Gram-positive and Gram-negative bacteria. NO was entrapped inside PSi NPs functionalized by means of the thermal hydrocarbonization (THC) process. Subsequent reduction of nitrite in the presence of D-glucose led to the production of large NO payloads without reducing the biocompatibility of the PSi NPs with mammalian cells. The resulting PSi NPs demonstrated sustained release of NO and showed remarkable antibacterial efficiency and anti-biofilm-forming properties. These results will set the stage to develop antimicrobial nanoparticle formulations for applications in chronic wound treatment.
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2014 Kafshgari et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. (http://creativecommons.org/licenses/by/4.0)