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Pulmonary vascular regulation in the fetal and transitional lung

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dc.contributor.authorHolmes, H.
dc.contributor.authorSaini, B.S.
dc.contributor.authorMoir, O.J.
dc.contributor.authorDarby, J.R.T.
dc.contributor.authorMorrison, J.L.
dc.contributor.authorSun, L.
dc.contributor.authorSeed, M.
dc.date.issued2024
dc.description.abstractFetal lungs have fewer and smaller arteries with higher pulmonary vascular resistance (PVR) than a newborn. As gestation advances, the pulmonary circulation becomes more sensitive to changes in pulmonary arterial oxygen tension, which prepares them for the dramatic drop in PVR and increase in pulmonary blood flow (PBF) that occur when the baby takes its first few breaths of air, thus driving the transition from fetal to postnatal circulation. Dynamic and intricate regulatory mechanisms control PBF throughout development and are essential in supporting gas exchange after birth. Understanding these concepts is crucial given the role the pulmonary vasculature plays in the development of complications with transition, such as in the setting of persistent pulmonary hypertension of the newborn and congenital heart disease. An improved understanding of pulmonary vascular regulation may reveal opportunities for better clinical management.
dc.identifier.citationClinics in Perinatology, 2024; 51(1):1-19
dc.identifier.doi10.1016/j.clp.2023.11.003
dc.identifier.issn0095-5108
dc.identifier.issn1557-9840
dc.identifier.urihttps://hdl.handle.net/11541.2/37124
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright 2023 Elsevier Access Condition Notes: Accepted manuscript available after 1 January 2025
dc.source.urihttps://doi.org/10.1016/j.clp.2023.11.003
dc.subjectfetal lung
dc.subjectpulmonary blood flow
dc.subjectpulmonary circulation
dc.subjectpulmonary vascular tone
dc.subjectpulmonary vasculature
dc.titlePulmonary vascular regulation in the fetal and transitional lung
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12278567450001831 13278577320001831 Open Access Postprint
ror.mmsid9916813829001831

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