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Formulation development and dissolution rate enhancement of efavirenz by solid dispersion systems

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dc.contributor.authorKoh, P.T.
dc.contributor.authorChuah, J.N.
dc.contributor.authorTalekar, M.
dc.contributor.authorGorajana, A.
dc.contributor.authorGarg, S.
dc.date.issued2013
dc.descriptionLink to a related website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783747/pdf, Open Access via Unpaywall
dc.description.abstractThe aim of this study was to enhance the dissolution rate of efavirenz using solid dispersion systems (binary and ternary). A comparison between solvent and fusion method was also investigated. Solid dispersions of efavirenz were prepared using polyethylene glycol 8000, polyvinylpyrrolidone K30 alone and combination of both. Tween 80 was incorporated to obtain a ternary solid dispersion system. Dissolution tests were conducted and evaluated on the basis of cumulative percentage drug release and dissolution efficiency. Physicochemical characterizations of the solid dispersions were carried out using differential scanning calorimetric, powder X‑ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. Dissolution was remarkably improved in both systems compared to pure efavirenz (P<0.05). An optimum ratio was identified at a drug:polymer of 1:10. Incorporation of Tween 80 to 1:10 formulations formed using solvent method showed further improvement in the dissolution rate. Physicochemical characterization results suggested that efavirenz existed in the amorphous form in all the solid dispersion systems providing evidence of improvement in dissolution. No statistically significant difference (P>0.05) in dissolution was observed between the two methods. Binary and ternary solid dispersion systems both have showed a significant improvement in the dissolution rate of efavirenz. Formulations with only polyvinylpyrrolidone K30 showed best dissolution profile and 1:10 was identified as an optimum drug‑polymer weight ratio.
dc.identifier.citationINDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013; 75(3):291-301
dc.identifier.doi10.4103/0250-474X.117434
dc.identifier.issn0250-474X
dc.identifier.issn1998-3743
dc.identifier.orcidGarg, S. [0000-0001-7253-2629]
dc.identifier.urihttps://hdl.handle.net/1959.8/155170
dc.language.isoen
dc.publisherMedknow Publications and Media
dc.rightsCopyright 2013 The Authors
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783747/pdf
dc.subjectdissolution enhancement
dc.subjectefavirenz
dc.subjectpolyethylene glycol
dc.subjectPVP K30
dc.subjectTween 80
dc.titleFormulation development and dissolution rate enhancement of efavirenz by solid dispersion systems
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915909986901831

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