Remarkably decreased CD11b positive splenocytes in aquaporin 3-null mice
Date
2010
Authors
Zhu, N.
Qiao, Y.
Zhang, D.
Wang, W.J.
Liu, J.
Liu, T.Z.
Ma, T.H.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Chemical Research in Chinese Universities, 2010; 26(2):217-220
Statement of Responsibility
Conference Name
Abstract
Aquaporins (AQPs) are molecular water channels that play important physiological roles in fluid transporting organs. The expression and function of AQPs in the immune system are largely unknown. CD11(a-d)/CD18 integrins are adhesion molecules expressed on leukocytes, which play a critical role in leukocyte adhesion, migration and host defense. In the present study, we discovered the expression of aquaporin-3 (AQP3) on spleen CD11b positive cells, and the content of CD11b positive splenocytes in aquaporin 3-null mice is significantly decreased. Further analysis suggested remarkably decreased monocyte/macrophage subpopulation and significantly decreased granulocyte subpopulation. It is the first report suggesting an important role of AQP in the development and maturation of immunocytes.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2010 Jilin University