A pharmacokinetic study of 5-fluorouracil in tumour tissue using microdialysis /
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(Published version)
Date
2009
Authors
Zhang, Shuangjie,
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thesis
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Abstract
In order for chemotherapy to be successful in cancer patients, it is desirable that optimal quantities of the anticancer agents reach the targeted tissue (e.g. a tumour) to the exclusion of other tissues. Therefore, it is important to have an understanding of the degree to which the anticancer drug is directed into tumours relative to other tissues. 5-Fluorouracil (5-FU) has been used in the treatment of various solid tumours for nearly 50 years. However, successful treatment with 5-FU may be influenced by inherent differences in vascularity, capillary permeability in tumour, and/or tumour interstitial pressure, along with adverse effects associated with its uptake into other tissues. One means of improving its effectiveness is to ensure more specific delivery to its site of action by using delivery systems, which target the drug to specific sites. To evaluate specificity in delivery into tissue requires measurement of the drug in different tissues and comparisons of exposure with normal tissue. Microdialysis is a valuable technique for measuring drugs in tissue, and this thesis describes investigations into the uptake of 5 - FU into tumour tissue, over time, as a prelude to future studies developing new delivery systems and assessment of their specificity in delivery to the site of action...
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
Dissertation Note
Thesis (PhD)--University of South Australia, 2009.
Provenance
Copyright 2009 Shuangjie Zhang.
Description
xxii, 228 leaves :
illustrations.
Includes bibliographic references.
illustrations.
Includes bibliographic references.
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